{"id":"W2070999406","doi":"10.1093/carcin/bgu326","title":"Inherited variants in the inner centromere protein (INCENP) gene of the chromosomal passenger complex contribute to the susceptibility of ER-negative breast cancer","year":2015,"lang":"en","type":"article","venue":"Carcinogenesis","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University and Génome Québec Innovation Centre; Université Laval; Royal Victoria Hospital; Centre hospitalier universitaire de Québec; Sante Montreal; McGill University; McGill University Health Centre; Université de Montréal; Royal Victoria Regional Health Centre; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; Public Health Ontario; University of Toronto","funders":"National Cancer Institute; Universitätsklinikum Hamburg-Eppendorf; Instituto de Salud Carlos III; Medical Research Council; National Institutes of Health; Akershus Universitetssykehus; Rheinische Friedrich-Wilhelms-Universität Bonn; Ministero dello Sviluppo Economico; Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail; National Health and Medical Research Council; Oulun Yliopisto; Deutsche Krebshilfe; Medizinischen Hochschule Hannover; Norges Forskningsråd; Institut National Du Cancer; Leids Universitair Medisch Centrum; Universitetet i Bergen; Stockholms Läns Landsting; Kuopion Yliopistollinen Sairaala; Karolinska Institutet; Canadian Institutes of Health Research; General Secretariat for Research and Technology; Ovarian Cancer Research Fund; Bundesministerium für Bildung und Forschung; Ministerio de Economía y Competitividad; Deutsche Gesetzliche Unfallversicherung; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Fonds Wetenschappelijk Onderzoek; Cancerfonden; Cancer Australia; Agence Nationale de la Recherche; Robert Bosch Stiftung; National Breast Cancer Foundation; European Commission; Herlev Hospital; University of Southern California; Associazione Italiana per la Ricerca sul Cancro; Beckman Research Institute, City of Hope; Cancer Research UK; Eberhard Karls Universität Tübingen; Fondation du cancer du sein du Québec; King's College London; Academy of Finland; Génome Québec; National Institute for Health and Care Research; Itä-Suomen Yliopisto; Ministère du Développement Économique, de l’Innovation et de l’Exportation; Lon V. Smith Foundation; European Social Fund; Agency for Science, Technology and Research; Francis Crick Institute; McGill University Health Centre; University of California, Irvine; David F. and Margaret T. Grohne Family Foundation; Medisinske fakultet, Universitetet i Oslo; Ligue Contre le Cancer; Deutsches Krebsforschungszentrum; Breast Cancer Research Foundation; McGill University; Helsingin ja Uudenmaan Sairaanhoitopiiri; Susan G. Komen for the Cure; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Fondation de France; Universitetet i Oslo; Sundhed og Sygdom, Det Frie Forskningsråd; Cancer Council Victoria; California Department of Public Health; Haukeland Universitetssjukehus; U.S. Department of Health and Human Services; Universitetet i Tromsø; University of Cambridge","keywords":"Single-nucleotide polymorphism; Breast cancer; Genetics; Biology; Allele; Odds ratio; Estrogen receptor; Oncology; SNP; Cancer; Genotype; Internal medicine; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000453321,0.0001697516,0.0002401917,0.00002148692,0.00007197428,0.00001398235,0.0006196974,0.0001064072,0.00002032837],"category_scores_gemma":[0.0001100666,0.00009327626,0.0001106393,0.0003067583,0.0001780217,0.00000321728,0.0002579106,0.00008616636,0.000001182557],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006302616,"about_ca_system_score_gemma":0.0002370679,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001286574,"about_ca_topic_score_gemma":0.002876366,"domain_scores_codex":[0.9985506,0.0003392545,0.0003389026,0.0002788362,0.0002342918,0.0002581443],"domain_scores_gemma":[0.9986333,0.00002324989,0.0001947006,0.0007252323,0.0003592473,0.00006429301],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001303332,0.0001082769,0.07319023,0.00002729443,0.00006601962,0.00000123246,0.0006665176,0.000591632,0.9243352,0.00004455072,0.000444741,0.0003940106],"study_design_scores_gemma":[0.0007118644,0.0000883235,0.8133887,0.00002088082,0.00003316422,0.00001070472,0.000549378,0.0004054044,0.1842756,0.00005201331,0.0003398501,0.0001240961],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958946,0.0002767528,0.00005650465,0.001704799,0.00008828843,0.0008808725,0.001048348,0.000002504029,0.00004730434],"genre_scores_gemma":[0.9992517,0.0000203239,0.0001588071,0.0002707423,0.0001133749,0.00009106168,0.00004543026,0.00001747864,0.0000311424],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7401985,"threshold_uncertainty_score":0.3803695,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01897547237737718,"score_gpt":0.2428290898528583,"score_spread":0.2238536174754811,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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