{"id":"W2071047341","doi":"10.1038/srep02871","title":"Structural basis for a class of nanomolar influenza A neuraminidase inhibitors","year":2013,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"British Columbia Centre for Disease Control; Provincial Health Services Authority; Medical Research Council; University of St Andrews; Natural Sciences and Engineering Research Council of Canada; Scottish Funding Council","keywords":"Neuraminidase; Binding site; Chemistry; Virus; Hydrogen bond; Influenza A virus; In vitro; Computational biology; Virology; Biology; Biochemistry; Molecule","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009057789,0.0003415611,0.0003682632,0.00008891544,0.0002571329,0.0002995387,0.0005508799,0.0003019912,0.001868064],"category_scores_gemma":[0.0001312448,0.0001879624,0.0002028622,0.0000596217,0.0003070497,0.0002250759,0.0002743704,0.0005357093,0.0004911686],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003012079,"about_ca_system_score_gemma":0.0002982791,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005859397,"about_ca_topic_score_gemma":0.0007316655,"domain_scores_codex":[0.9999143,0.000009270912,0.000005714292,0.00001824415,0.00003542007,0.00001704736],"domain_scores_gemma":[0.9999462,0.00001015163,0.00001738624,0.000004239987,0.000008019707,0.00001403728],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003330213,0.0001699001,0.0006841754,0.0001399009,0.00002831437,0.0002678304,0.00004612433,0.007736714,0.9714729,0.007421369,0.0006283252,0.0110714],"study_design_scores_gemma":[0.0002768974,0.003172979,0.004092644,0.00004741825,0.0001033648,0.00193375,0.0001413198,0.04131601,0.8914885,0.006569018,0.05077821,0.00007980884],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9199616,0.00760381,0.0476789,0.00100181,0.0002065459,0.0003298065,0.0004986082,0.0004443902,0.0222747],"genre_scores_gemma":[0.9841816,0.001959967,0.01096966,0.0003730922,0.00002200427,0.00009257281,0.0003447763,0.00002546274,0.002030723],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001868064,"threshold_uncertainty_score":0.006249309,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06061830155935807,"score_gpt":0.3519659117004009,"score_spread":0.2913476101410428,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}