{"id":"W2071048491","doi":"10.1002/(sici)1097-4652(200007)184:1<17::aid-jcp2>3.0.co;2-u","title":"Cell-cycle-dependent turnover of P-glycoprotein in multidrug-resistant cells","year":2000,"lang":"en","type":"article","venue":"Journal of Cellular Physiology","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre","funders":"Amgen","keywords":"Cell cycle; Cell growth; Cell culture; Biology; Colchicine; Cell; Chinese hamster ovary cell; Cell division; DNA synthesis; Molecular biology; Cell biology; Biochemistry; In vitro; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000347796,0.0001971764,0.0007960639,0.0002110967,0.00002392886,0.000003700042,0.000191714,0.0001760767,0.001334781],"category_scores_gemma":[0.00000698733,0.0001477522,0.0003155939,0.0001757911,0.00009707146,0.00007231256,0.00001221708,0.0004463976,0.00003372059],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006240818,"about_ca_system_score_gemma":0.0001414989,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004079657,"about_ca_topic_score_gemma":0.00001438674,"domain_scores_codex":[0.9980934,0.00009025185,0.0009225123,0.0001957285,0.0003810332,0.0003170451],"domain_scores_gemma":[0.9990159,0.00003936644,0.0004131377,0.0002691235,0.0001222419,0.0001401977],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00229482,0.0007161294,0.00008194992,0.0001980173,0.00005462892,0.0006495775,0.0002612622,0.0006397539,0.9941101,0.00003734687,0.00009763546,0.0008587644],"study_design_scores_gemma":[0.004384071,0.0007254144,0.006590371,0.0002460265,0.0001024683,0.00004549198,0.0001553492,0.0001137614,0.9844546,0.0006055735,0.002420816,0.000156028],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965044,0.001177038,0.0001736496,0.0001166148,0.000259974,0.0002289647,0.000007330804,0.00000709098,0.001524963],"genre_scores_gemma":[0.9964858,0.0003170427,0.0009830077,0.00007435699,0.0001913451,0.000002495416,0.00000534023,0.00002902243,0.001911543],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009655484,"threshold_uncertainty_score":0.9995781,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004831496449940291,"score_gpt":0.2096654977029825,"score_spread":0.2048340012530422,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}