{"id":"W2071061747","doi":"10.1016/j.vaccine.2009.01.039","title":"Use of predictive markers of HIV disease progression in vaccine trials","year":2009,"lang":"en","type":"review","venue":"Vaccine","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sanofi (Canada)","funders":"","keywords":"Viral load; Clinical trial; Medicine; Clinical endpoint; Immunology; Surrogate endpoint; HIV vaccine; Disease; Vaccine efficacy; Transmission (telecommunications); Licensure; Clinical study design; Vaccine trial; Virology; Vaccination; Intensive care medicine; Virus; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004753801,0.001576828,0.00487496,0.002155472,0.0001943089,0.001491696,0.001513234,0.001819676,0.001922001],"category_scores_gemma":[0.008152095,0.0005286041,0.001126887,0.001898257,0.0007223052,0.001328966,0.0006268169,0.002987485,0.0007800102],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001102334,"about_ca_system_score_gemma":0.001943997,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001456152,"about_ca_topic_score_gemma":0.002515333,"domain_scores_codex":[0.9987534,0.0004420204,0.0002465497,0.0001983411,0.000298351,0.00006125843],"domain_scores_gemma":[0.9932551,0.005135393,0.0007293528,0.0001142772,0.000645017,0.0001207341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004600421,0.00008282704,0.0005179957,0.01601891,0.0003283373,0.0001207746,0.00002224774,0.0004615657,0.0006109578,0.001356208,0.01521903,0.9648011],"study_design_scores_gemma":[0.00101809,0.001545496,0.006008856,0.04104576,0.004583179,0.002641538,0.000130719,0.001189237,0.002341462,0.005936394,0.9334389,0.0001203997],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007927571,0.9989282,0.0002303163,0.0002613977,0.000204567,0.00001234871,0.00002417521,0.000005691593,0.0002539101],"genre_scores_gemma":[0.001782901,0.9960989,0.0007887334,0.0006163043,0.0004326067,0.0000325294,0.00006265514,0.000002595062,0.000182767],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00487496,"threshold_uncertainty_score":0.02514076,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0656411902949607,"score_gpt":0.3732897242556882,"score_spread":0.3076485339607275,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}