{"id":"W2071061894","doi":"10.1210/en.2003-0222","title":"Hyperleptinemia, Visceral Adiposity, and Decreased Glucose Tolerance in Mice with a Targeted Disruption of the Histidine Decarboxylase Gene","year":2003,"lang":"en","type":"article","venue":"Endocrinology","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Stockholms Universitet","keywords":"Histidine decarboxylase; Endocrinology; Internal medicine; Histaminergic; Histamine; Leptin; Adipose tissue; Brown adipose tissue; Biology; Orexigenic; Adipokine; Energy homeostasis; Thermogenesis; White adipose tissue; Medicine; Obesity; Histidine; Enzyme; Neuropeptide Y receptor; Neuropeptide; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005046227,0.0001119638,0.0001673057,0.00006873715,0.00007475241,0.000008246455,0.0001313684,0.00003890972,0.00003041326],"category_scores_gemma":[0.0001842197,0.00008119696,0.00002744239,0.0002433164,0.0002217413,0.00007024672,0.00004373815,0.0001205221,0.000003606242],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002878057,"about_ca_system_score_gemma":0.00004074329,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000114412,"about_ca_topic_score_gemma":0.0002009685,"domain_scores_codex":[0.9989882,0.0001928963,0.000179326,0.0002823145,0.0001198334,0.000237491],"domain_scores_gemma":[0.9995323,0.0001012802,0.00009427347,0.0001982196,0.00002545732,0.00004846994],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001238021,0.0001101868,0.0734169,0.00001145214,0.000002898623,0.00002749794,0.00009166851,0.0002533994,0.9219665,0.003623682,0.00001151795,0.0003604978],"study_design_scores_gemma":[0.001006542,0.00008188593,0.2290723,0.00001273392,0.000008649536,0.0001428209,0.000007602911,0.000308798,0.7684701,0.0001581806,0.0006505813,0.00007980019],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998386,0.0002158269,0.00008127032,0.0002784023,0.00007638102,0.0001963097,0.000005402936,0.00001937366,0.0007409833],"genre_scores_gemma":[0.9990048,0.00007128034,0.0005072692,0.0002442806,0.0000149212,0.00001051543,0.000001391146,0.000008456508,0.0001370161],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1556554,"threshold_uncertainty_score":0.3311116,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01175198037881875,"score_gpt":0.2307572843084095,"score_spread":0.2190053039295907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}