{"id":"W2071061894","doi":"10.1210/en.2003-0222","title":"Hyperleptinemia, Visceral Adiposity, and Decreased Glucose Tolerance in Mice with a Targeted Disruption of the Histidine Decarboxylase Gene","year":2003,"lang":"en","type":"article","venue":"Endocrinology","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Stockholms Universitet","keywords":"Histidine decarboxylase; Endocrinology; Internal medicine; Histaminergic; Histamine; Leptin; Adipose tissue; Brown adipose tissue; Biology; Orexigenic; Adipokine; Energy homeostasis; Thermogenesis; White adipose tissue; Medicine; Obesity; Histidine; Enzyme; Neuropeptide Y receptor; Neuropeptide; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002040811,0.00128823,0.0004377477,0.001361934,0.0002976081,0.0005364625,0.00026289,0.0007259837,0.002893678],"category_scores_gemma":[0.0001795292,0.0004706723,0.0003387073,0.000324345,0.000683237,0.0004096672,0.000311009,0.001332616,0.0005613985],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004441989,"about_ca_system_score_gemma":0.0002332005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008022728,"about_ca_topic_score_gemma":0.00166897,"domain_scores_codex":[0.9997405,0.00003170396,0.00003148509,0.00008088596,0.00006598409,0.00004934153],"domain_scores_gemma":[0.9996392,0.00002506021,0.0001578161,0.00002374088,0.00001637531,0.0001379589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003856679,0.0001348347,0.0006826723,0.00002759648,0.00002238389,0.0002978169,0.00004306336,0.00006208875,0.9967412,0.0001523705,0.000107592,0.001342808],"study_design_scores_gemma":[0.0005787247,0.003470994,0.1307234,0.00008041568,0.0003026986,0.009346585,0.0002790295,0.002632034,0.8457807,0.0008076554,0.005937372,0.00006034217],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937438,0.000907183,0.002314381,0.0002579571,0.0000479879,0.00003131152,0.001254434,0.0003397532,0.001103108],"genre_scores_gemma":[0.9827434,0.001519753,0.004700361,0.0002280214,0.00005298762,0.0001121959,0.002099925,0.0002419883,0.008301383],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002893678,"threshold_uncertainty_score":0.009680331,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01175198037881875,"score_gpt":0.2307572843084095,"score_spread":0.2190053039295907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}