{"id":"W2071136213","doi":"10.1038/oby.2011.144","title":"Metabolic Syndrome and Acute Hyperglycemia Are Associated With Endoplasmic Reticulum Stress in Human Mononuclear Cells","year":2011,"lang":"en","type":"article","venue":"Obesity","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hamilton Health Sciences; McMaster University; Thrombosis and Atherosclerosis Research Institute","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Unfolded protein response; Endoplasmic reticulum; Calreticulin; Internal medicine; Endocrinology; Peripheral blood mononuclear cell; Glucose-regulated protein; Medicine; Diabetes mellitus; Biology; In vitro; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007629158,0.0002167138,0.0002779623,0.00005124198,0.00009693368,0.00002361486,0.0001630832,0.0001586742,0.00004337054],"category_scores_gemma":[0.00002352577,0.0001904349,0.00005739626,0.00009382302,0.0001371951,0.00000900489,0.0001259566,0.0001348392,0.000006737287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000109283,"about_ca_system_score_gemma":0.0000285761,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001574221,"about_ca_topic_score_gemma":0.0003634897,"domain_scores_codex":[0.9988602,0.00007730603,0.0001767835,0.0004388626,0.0001273376,0.0003194881],"domain_scores_gemma":[0.9993332,0.000007651964,0.000118545,0.0003268421,0.00004601988,0.0001677528],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001844225,0.0005450158,0.8478943,0.00003583751,0.0002317483,0.0005573556,0.0001639112,0.00002298567,0.1499918,0.0001592663,0.0001695121,0.0000438203],"study_design_scores_gemma":[0.001453883,0.0002952334,0.6458684,0.00007327715,0.0001356725,0.00004697193,0.0001428025,0.00002919744,0.3514616,0.00006621424,0.00009024156,0.000336501],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977977,0.0003114827,0.00001013175,0.000009154398,0.00004115314,0.0001803732,0.0001099192,0.00002068455,0.001519389],"genre_scores_gemma":[0.9991336,0.0002232594,0.0001392824,0.0000561034,0.00001782863,0.00001786628,0.00007306678,0.00002883852,0.0003101453],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2020259,"threshold_uncertainty_score":0.776571,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00743250915114636,"score_gpt":0.1988403369445378,"score_spread":0.1914078277933914,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}