{"id":"W2071149267","doi":"10.1074/jbc.m110.135483","title":"Activity-based Protein Profiling Identifies a Host Enzyme, Carboxylesterase 1, Which Is Differentially Active during Hepatitis C Virus Replication","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Hepatitis C virus research","field":"Medicine","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; University of Alberta; National Research Council Canada; University of Ottawa; Steacie Institute for Molecular Sciences","funders":"Canadian Institutes of Health Research; Canadian Liver Foundation","keywords":"Hepatitis C virus; Biology; Hepacivirus; Enzyme; Virology; Virus; Viral replication; Carboxylesterase; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002441211,0.0002964564,0.0003066515,0.0005657365,0.0001599941,0.0004222379,0.0001252129,0.0003320856,0.0006544836],"category_scores_gemma":[0.0002403251,0.0001439178,0.0002851964,0.0004144751,0.0001990174,0.0002387326,0.0001638714,0.000371565,0.0003590216],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002476113,"about_ca_system_score_gemma":0.0001295714,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003857776,"about_ca_topic_score_gemma":0.0006109297,"domain_scores_codex":[0.9998405,0.00002270387,0.0000129608,0.00004428847,0.00004826053,0.0000312069],"domain_scores_gemma":[0.9998542,0.0000438631,0.00003707191,0.00001482337,0.0000265578,0.00002348649],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005493085,0.000005703225,0.0005492174,0.00001682303,0.000003758431,0.000009518153,0.000005885663,0.00002246487,0.9982911,0.00001979839,0.00001119041,0.001009472],"study_design_scores_gemma":[0.00000317574,0.00008524636,0.0242868,0.000002793292,0.00002003236,0.000202957,0.00001888599,0.001050636,0.9734161,0.00005241029,0.000855574,0.000005441438],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9835283,0.002414699,0.01140165,0.0001043585,0.0000165595,0.00003359777,0.001316842,0.00008889928,0.001095134],"genre_scores_gemma":[0.9810414,0.001791569,0.01287039,0.00008009102,0.0000124265,0.00003513091,0.002121147,0.00003773798,0.00201028],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006544836,"threshold_uncertainty_score":0.002189457,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02958380627365121,"score_gpt":0.313568642041861,"score_spread":0.2839848357682098,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}