{"id":"W2071285382","doi":"10.1159/000337004","title":"Role of DNA Methylation in Colorectal Carcinogenesis","year":2012,"lang":"en","type":"review","venue":"Digestive Diseases","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"AGE-WELL","keywords":"Colorectal cancer; Epigenetics; Medicine; DNA methylation; Carcinogenesis; Malignancy; Colonoscopy; Cancer research; Cancer; Mouse model of colorectal and intestinal cancer; Bioinformatics; Oncology; Internal medicine; Biology; Genetics; Gene; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001161897,0.0002658961,0.0006251878,0.0001426927,0.00002493936,0.00000806816,0.0001455953,0.0002628521,0.00001317255],"category_scores_gemma":[0.000148667,0.0002430738,0.0003205627,0.0001877802,0.00006301158,0.000003788577,0.00008467303,0.00006627741,0.000006803713],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003325146,"about_ca_system_score_gemma":0.0001914635,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002565549,"about_ca_topic_score_gemma":0.00001248908,"domain_scores_codex":[0.9987176,0.0002144112,0.0003924964,0.0003240024,0.0001363966,0.0002150788],"domain_scores_gemma":[0.9992439,0.00006507027,0.0002843513,0.0002187532,0.00008811731,0.00009983138],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003246592,0.0002031126,0.02295057,0.001550485,0.0001213538,0.000001063858,0.00003181933,0.00001294354,0.01397421,0.00005745236,0.000003523025,0.961061],"study_design_scores_gemma":[0.0004503043,0.0003593748,0.1730358,0.001750322,0.002133227,0.000002150047,0.00007543121,0.000008535276,0.05884191,0.0001902264,0.7620659,0.001086795],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.05758652,0.9412429,0.00001505155,7.51503e-7,0.00006860842,0.0004059115,0.000348065,0.000005006209,0.0003271398],"genre_scores_gemma":[0.147448,0.8505862,0.00003015558,0.000001679891,0.0001466683,0.00009796816,0.001629734,0.0000361126,0.00002344199],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9599742,"threshold_uncertainty_score":0.9912261,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02333184130846662,"score_gpt":0.3049281682768519,"score_spread":0.2815963269683853,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}