{"id":"W2071311218","doi":"10.1016/j.bbamcr.2008.03.014","title":"Photoexcited calphostin C selectively destroys nuclear lamin B1 in neoplastic human and rat cells — A novel mechanism of action of a photodynamic tumor therapy agent","year":2008,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute for Biological Sciences","funders":"Università degli Studi di Verona; University of British Columbia","keywords":"Lamin; Nuclear lamina; Cell biology; Calphostin C; Nuclear protein; Biology; Apoptosis; Molecular biology; Chemistry; Biochemistry; Nucleus; Protein kinase C; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003080785,0.0002967034,0.000356806,0.0003405554,0.000148476,0.00002465149,0.0002924502,0.0002248893,0.00001531158],"category_scores_gemma":[0.00004105843,0.0002935402,0.0001489633,0.0005574137,0.0003668386,0.00001333227,0.000195961,0.0004230102,0.000004039603],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000054369,"about_ca_system_score_gemma":0.0001722949,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003556106,"about_ca_topic_score_gemma":0.00003095846,"domain_scores_codex":[0.9977382,0.0002591511,0.0003867475,0.0006700503,0.0004814113,0.0004644296],"domain_scores_gemma":[0.9989399,0.00004247915,0.0002062546,0.0004487106,0.0002378349,0.0001248159],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007355921,0.000461842,0.000008546036,0.00007897577,0.00006206535,0.00001880972,0.0003105023,0.00001289402,0.998038,0.000107864,0.00009475023,0.00007015483],"study_design_scores_gemma":[0.001552546,0.001648988,0.002469809,0.00003718541,0.00001703528,0.00002089119,0.0001421168,0.0005024975,0.9931278,0.00007282784,0.0001550318,0.0002532251],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987822,0.00007514431,0.0001545968,0.0000330726,0.00006283572,0.0006316338,0.00003061402,0.00001774382,0.0002121767],"genre_scores_gemma":[0.9986606,0.000391026,0.0005937597,0.00007297794,0.00003954123,0.00002609409,0.00005612541,0.00009213314,0.00006771512],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004910158,"threshold_uncertainty_score":0.9999517,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03313942340621944,"score_gpt":0.2931568983073013,"score_spread":0.2600174749010818,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}