{"id":"W2071315558","doi":"10.3839/jabc.2011.010","title":"The Roles of Hydroxyl Substituents in Tyrosinase Inhibitory Activation of Flavone Analogues","year":2011,"lang":"en","type":"article","venue":"Journal of Applied Biological Chemistry","topic":"melanin and skin pigmentation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Tyrosinase; Chemistry; Stereochemistry; Active site; Substrate (aquarium); Molecule; Protein Data Bank (RCSB PDB); Docking (animal); Enzyme; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003179546,0.00008422579,0.0001629116,0.00001811246,0.00002282768,0.0000030709,0.000176784,0.000155943,0.00001318782],"category_scores_gemma":[0.00007147564,0.00005247655,0.00007226329,0.00006455608,0.0001476213,0.000003105837,0.00004012233,0.0001049247,3.301697e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001226689,"about_ca_system_score_gemma":0.00003224261,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002033703,"about_ca_topic_score_gemma":0.000001823182,"domain_scores_codex":[0.9992307,0.00002249902,0.0004359449,0.00009891127,0.0001139765,0.00009792126],"domain_scores_gemma":[0.999293,0.0000262942,0.000454949,0.0001129059,0.00007681539,0.00003598658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006777833,0.0001302219,0.003039869,0.00001776305,0.00002652984,0.000001548602,0.00006830868,0.00001113937,0.9951783,0.00004948521,0.0000759445,0.0007230588],"study_design_scores_gemma":[0.0004726641,0.0001359981,0.006926074,0.00002394148,0.000007118238,0.000005675904,0.0003319123,0.00000301063,0.9914501,0.0004561994,0.0001310756,0.00005625432],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974333,0.0002609975,0.00008873338,0.000009167838,0.00003214612,0.00004967742,0.000003463119,0.000001152821,0.002121332],"genre_scores_gemma":[0.9992449,0.0003415196,0.0002622508,0.00001591571,0.00009641873,0.000002654027,0.00002193482,0.000003776737,0.00001065946],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003886205,"threshold_uncertainty_score":0.2139932,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02077985890694914,"score_gpt":0.2320741460738838,"score_spread":0.2112942871669347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}