{"id":"W2071315558","doi":"10.3839/jabc.2011.010","title":"The Roles of Hydroxyl Substituents in Tyrosinase Inhibitory Activation of Flavone Analogues","year":2011,"lang":"en","type":"article","venue":"Journal of Applied Biological Chemistry","topic":"melanin and skin pigmentation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Tyrosinase; Chemistry; Stereochemistry; Active site; Substrate (aquarium); Molecule; Protein Data Bank (RCSB PDB); Docking (animal); Enzyme; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000124657,0.0002286392,0.0001927274,0.0000553464,0.0001355868,0.0002175766,0.0002529175,0.0002088166,0.002756058],"category_scores_gemma":[0.0001582763,0.00009290022,0.0002958335,0.00008443186,0.0001502265,0.0002456307,0.000134547,0.0003934698,0.0003519137],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002287528,"about_ca_system_score_gemma":0.0001875396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001378506,"about_ca_topic_score_gemma":0.001427385,"domain_scores_codex":[0.9999306,0.00001108345,0.000002901482,0.00001494376,0.00001669562,0.0000238262],"domain_scores_gemma":[0.9999524,0.00001249028,0.00001113543,0.000004535983,0.00000668076,0.00001274086],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009372382,0.0001237236,0.0008237296,0.0002440819,0.00004649888,0.0003947888,0.00008722899,0.004635225,0.9795942,0.001990439,0.0007665135,0.01035633],"study_design_scores_gemma":[0.0001607097,0.0009037933,0.004633617,0.00002656287,0.00005735605,0.0003749627,0.0001134921,0.01363056,0.967109,0.0005394903,0.01240232,0.00004807319],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990469,0.002224541,0.001951272,0.0001052388,0.0000380268,0.00001650287,0.0002242331,0.0000540035,0.004917149],"genre_scores_gemma":[0.9948007,0.0009719571,0.001334078,0.00005202368,0.00000553377,0.00001071848,0.0003367554,0.00001874383,0.00246949],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002756058,"threshold_uncertainty_score":0.009219944,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02077985890694914,"score_gpt":0.2320741460738838,"score_spread":0.2112942871669347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}