{"id":"W2071337957","doi":"10.1002/1098-2280(2000)35:4<328::aid-em7>3.0.co;2-c","title":"Activation of MeIQ (2-amino-3,4-dimethylimidazo- [4,5-f]quinoline) by sequence variants of recombinant human cytochrome P450 1A2","year":2000,"lang":"en","type":"article","venue":"Environmental and Molecular Mutagenesis","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Mutagen; Mutagenesis; Escherichia coli; Carcinogen; Enzyme; Recombinant DNA; Quinoline; Biochemistry; Mutant; Mutation; Biology; Cytochrome P450; Enterobacteriaceae; Molecular biology; Chemistry; Genetics; Gene; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002930915,0.0002632016,0.0003691574,0.00008406739,0.0001387233,0.00000636909,0.0002176049,0.0002161062,0.002686739],"category_scores_gemma":[0.000006403532,0.0002677217,0.0001165389,0.0001002141,0.0003418915,0.00008464176,0.00008989762,0.0002041504,0.00003096547],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003464231,"about_ca_system_score_gemma":0.00001776987,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000425185,"about_ca_topic_score_gemma":3.94489e-7,"domain_scores_codex":[0.9983132,0.0002931899,0.0004673584,0.0003838675,0.0002228447,0.000319478],"domain_scores_gemma":[0.9993259,0.00005055499,0.000197357,0.0002278547,0.00001044724,0.0001878347],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001047003,0.0005053089,0.0005685496,0.00003970859,0.0001965558,0.00001822971,0.0002392825,0.0001678725,0.9542401,0.00006007557,0.0001347214,0.04372485],"study_design_scores_gemma":[0.001433886,0.0001507378,0.0189173,0.00001240867,0.000261785,0.00001516267,0.00003980437,0.0002577256,0.9641858,0.0002139841,0.01424498,0.0002663886],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956716,0.002743662,0.00009168838,0.00008790725,0.0001112997,0.0003343456,0.0001984187,0.00001667239,0.0007444396],"genre_scores_gemma":[0.9950586,0.003343437,0.0002462169,0.0004668577,0.00003194957,0.00002918313,0.0001312099,0.00003278262,0.0006597589],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04345847,"threshold_uncertainty_score":0.9999775,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04595138863415962,"score_gpt":0.3549589012813368,"score_spread":0.3090075126471772,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}