{"id":"W2071337957","doi":"10.1002/1098-2280(2000)35:4<328::aid-em7>3.0.co;2-c","title":"Activation of MeIQ (2-amino-3,4-dimethylimidazo- [4,5-f]quinoline) by sequence variants of recombinant human cytochrome P450 1A2","year":2000,"lang":"en","type":"article","venue":"Environmental and Molecular Mutagenesis","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Mutagen; Mutagenesis; Escherichia coli; Carcinogen; Enzyme; Recombinant DNA; Quinoline; Biochemistry; Mutant; Mutation; Biology; Cytochrome P450; Enterobacteriaceae; Molecular biology; Chemistry; Genetics; Gene; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002620731,0.0004258409,0.0002883427,0.000169612,0.0001025713,0.0001986968,0.0002313727,0.0002637103,0.001058831],"category_scores_gemma":[0.0003016476,0.0001940155,0.0002554685,0.0001573819,0.0001674302,0.0001136192,0.0002132351,0.0003438014,0.0003389347],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002458505,"about_ca_system_score_gemma":0.0001051607,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000835892,"about_ca_topic_score_gemma":0.001150749,"domain_scores_codex":[0.9996568,0.00009774388,0.00003196938,0.00008407378,0.00008111586,0.00004826671],"domain_scores_gemma":[0.9998521,0.00004779673,0.00003591282,0.00002941783,0.00001609999,0.00001879354],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004304885,0.0000118563,0.00008096299,0.000007474286,0.000002076409,0.00001071562,0.000005047073,0.00003720632,0.999487,0.000009244645,0.000005757268,0.000299685],"study_design_scores_gemma":[0.000007094775,0.0001915852,0.001523721,0.000001015225,0.000004252278,0.00008572493,0.000007101707,0.000285819,0.9975309,0.000007230403,0.000353498,0.000002044469],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956499,0.0004149164,0.003106152,0.00004432273,0.000008362557,0.00004155824,0.0002058641,0.0000425937,0.0004864351],"genre_scores_gemma":[0.9935163,0.0003469617,0.003834246,0.00002244117,0.000005726922,0.00003601291,0.0007878878,0.00002641498,0.001424109],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001058831,"threshold_uncertainty_score":0.003542125,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04595138863415962,"score_gpt":0.3549589012813368,"score_spread":0.3090075126471772,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}