{"id":"W2071355869","doi":"10.1128/aac.48.12.4829-4834.2004","title":"Molecular and Kinetic Comparison of the Novel Extended-Spectrum β-Lactamases CTX-M-25 and CTX-M-26","year":2004,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; Health Canada","funders":"","keywords":"Ceftazidime; Cefotaxime; Klebsiella pneumoniae; Plasmid; Biology; Escherichia coli; Microbiology; Enzyme kinetics; Beta-lactamase; Molecular biology; Enterobacteriaceae; Enzyme; Gene; Recombinant DNA; Bacteria; Genetics; Antibiotics; Biochemistry; Active site","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001504068,0.0004061799,0.0002537276,0.0002704993,0.00009026498,0.0004734947,0.0003326465,0.0002555075,0.0008401253],"category_scores_gemma":[0.000368319,0.0001340683,0.000290863,0.0002680123,0.0002265862,0.0002695706,0.000126498,0.0003944883,0.000312866],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008910792,"about_ca_system_score_gemma":0.0003770424,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009494094,"about_ca_topic_score_gemma":0.005713027,"domain_scores_codex":[0.9998249,0.00001059907,0.00001397509,0.00003989077,0.00007405038,0.00003660687],"domain_scores_gemma":[0.9997941,0.00003211131,0.00004662221,0.00001366324,0.00005008358,0.00006351926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006116437,0.0001223797,0.003744682,0.00006940558,0.00002957855,0.0001108787,0.00003449872,0.0005471754,0.9906287,0.0001341865,0.00006185187,0.003905132],"study_design_scores_gemma":[0.00005160875,0.001391491,0.07317692,0.00001515011,0.00005564145,0.001157268,0.0001364438,0.006292193,0.911368,0.0000692028,0.006254255,0.00003193833],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956893,0.002082827,0.000865092,0.00002852882,0.00001168813,0.0000204964,0.0003975698,0.00002153743,0.0008829932],"genre_scores_gemma":[0.9916762,0.001069256,0.002854231,0.0000151795,0.000007212591,0.00001519497,0.001867682,0.000009796596,0.00248521],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009494094,"threshold_uncertainty_score":0.01887769,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008542137380693609,"score_gpt":0.2507821333646156,"score_spread":0.242239995983922,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}