{"id":"W2071357105","doi":"10.1371/journal.pone.0071758","title":"No Evidence for Selection of HIV-1 with Enhanced Gag-Protease or Nef Function among Breakthrough Infections in the CAPRISA 004 Tenofovir Microbicide Trial","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; AIDS Vancouver","funders":"Canadian Institutes of Health Research; U.S. Public Health Service; Michael Smith Health Research BC; Department of Science and Technology, Ministry of Science and Technology, India; Sanofi; Claude Leon Foundation; National Research Foundation; Wellcome Trust; International Development Research Centre; United States Agency for International Development; National Institutes of Health; U.S. Department of Health and Human Services; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute","keywords":"Microbicide; Microbicides for sexually transmitted diseases; Protease; Virology; Group-specific antigen; Biology; Virus; Human immunodeficiency virus (HIV); Medicine; Enzyme; Population","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008192836,0.0004819604,0.001637304,0.0001889136,0.0006191833,0.001431625,0.0006956228,0.001380721,0.004147606],"category_scores_gemma":[0.006497639,0.0003046551,0.001099311,0.000313432,0.0006268466,0.0007236372,0.0002954485,0.001843656,0.0003455542],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004101045,"about_ca_system_score_gemma":0.0007895619,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004432533,"about_ca_topic_score_gemma":0.0008702112,"domain_scores_codex":[0.9962175,0.002038375,0.0002206368,0.0005355206,0.0005670483,0.0004208923],"domain_scores_gemma":[0.9932807,0.002902464,0.001102904,0.0007842025,0.0006025686,0.001327224],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.7347742,0.002028264,0.1618973,0.001188852,0.006364947,0.000736756,0.0007945791,0.0005110846,0.0304359,0.0006175766,0.002375507,0.05827493],"study_design_scores_gemma":[0.0840558,0.1522398,0.7252411,0.0003954951,0.009255623,0.002397304,0.0005279978,0.002629561,0.01240076,0.001314754,0.009407835,0.0001339041],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945669,0.002185565,0.0002661157,0.0002070618,0.00005943396,0.0001339438,0.0003254745,0.00001758926,0.002237845],"genre_scores_gemma":[0.9985775,0.0001970115,0.0001561243,0.0002254846,0.00003882792,0.00007403689,0.0002677454,0.000007568064,0.0004557372],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008192836,"threshold_uncertainty_score":0.0433284,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05378208674974629,"score_gpt":0.2724023117141136,"score_spread":0.2186202249643673,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}