{"id":"W2071370702","doi":"10.1182/blood-2013-03-491571","title":"Mutant IDH1 promotes leukemogenesis in vivo and can be specifically targeted in human AML","year":2013,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":208,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"","keywords":"IDH1; Mutant; In vivo; Cancer research; Bone marrow; Biology; CD34; Cell biology; Immunology; Stem cell; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001299977,0.0002740523,0.0002447526,0.0002123876,0.0001042118,0.0002393181,0.0001371556,0.0001845331,0.001404299],"category_scores_gemma":[0.00008023562,0.0001310365,0.0001182563,0.0001101771,0.0001632474,0.00008177376,0.0001264177,0.0004030737,0.0004000855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003174586,"about_ca_system_score_gemma":0.0001880026,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007142319,"about_ca_topic_score_gemma":0.0009751029,"domain_scores_codex":[0.9999177,0.00001147835,0.000005486706,0.00001759961,0.00002492892,0.00002280636],"domain_scores_gemma":[0.9999481,0.00001103579,0.00001223122,0.000005660004,0.000002994117,0.00001993519],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002383688,0.00007753491,0.0003367369,0.00002051716,0.000005163852,0.0000413982,0.00001089385,0.000142719,0.9969896,0.0001520365,0.0001073861,0.001877624],"study_design_scores_gemma":[0.00006158213,0.0007524958,0.005099232,0.000003268159,0.00001669693,0.000420084,0.00001270963,0.001299003,0.9887505,0.00004990927,0.003531326,0.000003171405],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947156,0.001658715,0.001444553,0.00007356547,0.00002242429,0.00003192579,0.0002825746,0.0001185755,0.001652049],"genre_scores_gemma":[0.9968842,0.0004344407,0.0007573793,0.00002537189,0.000004925387,0.00002187013,0.0004415465,0.00001147087,0.001418836],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001404299,"threshold_uncertainty_score":0.0046978,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02048177892487313,"score_gpt":0.2664981491730029,"score_spread":0.2460163702481297,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}