{"id":"W2071370702","doi":"10.1182/blood-2013-03-491571","title":"Mutant IDH1 promotes leukemogenesis in vivo and can be specifically targeted in human AML","year":2013,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":208,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"","keywords":"IDH1; Mutant; In vivo; Cancer research; Bone marrow; Biology; CD34; Cell biology; Immunology; Stem cell; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000272911,0.0001827372,0.0003746609,0.0003249534,0.0000473532,0.00003688002,0.0001438839,0.0001471678,0.000689996],"category_scores_gemma":[0.0001852528,0.0001567918,0.00003859009,0.0004164979,0.0001252574,0.00006086422,0.0001064522,0.0003568825,0.0000237236],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002180377,"about_ca_system_score_gemma":0.000241219,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003459302,"about_ca_topic_score_gemma":0.001535521,"domain_scores_codex":[0.9983283,0.00008112325,0.0003617122,0.0004007921,0.0003219643,0.000506085],"domain_scores_gemma":[0.9992383,0.00006870256,0.00004435251,0.0003394281,0.00007924831,0.0002299614],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003122938,0.0003962028,0.1048769,0.00007964067,0.00003655303,0.0004728869,0.0005785428,4.656394e-7,0.8920984,0.0001022891,0.0005197481,0.0008071518],"study_design_scores_gemma":[0.009550127,0.0005007038,0.3944123,0.0001477604,0.00004905402,0.0001588852,0.0004641882,0.0002433557,0.5931399,0.0002722286,0.0007668241,0.0002946231],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994234,0.0002169064,0.000001655611,0.00254853,0.00001662599,0.0009768907,0.00001371009,0.00004494584,0.001946684],"genre_scores_gemma":[0.998053,0.00007415083,0.0007469553,0.0002605931,0.000105087,0.0001041508,0.00001608461,0.00003942969,0.0006005876],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2989584,"threshold_uncertainty_score":0.7554972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02048177892487313,"score_gpt":0.2664981491730029,"score_spread":0.2460163702481297,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}