{"id":"W2071396207","doi":"10.1155/2014/810371","title":"Inhibition of MMP-2 Expression with siRNA Increases Baseline Cardiomyocyte Contractility and Protects against Simulated Ischemic Reperfusion Injury","year":2014,"lang":"en","type":"article","venue":"BioMed Research International","topic":"Cardiac Fibrosis and Remodeling","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; University of Saskatchewan","funders":"Canadian Institutes of Health Research; Saskatchewan Health Research Foundation; Heart and Stroke Foundation of Canada","keywords":"Contractility; Cell biology; Matrix metalloproteinase; Transfection; Intracellular; Paracrine signalling; Cardioprotection; Small interfering RNA; Biology; Ischemia; Chemistry; Internal medicine; Medicine; Endocrinology; Cell culture; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002746311,0.0004355062,0.0005602671,0.0002527664,0.0001488866,0.0003382418,0.0002067047,0.0003575728,0.001551133],"category_scores_gemma":[0.0001441882,0.0001618468,0.0003109521,0.0001459602,0.0002332401,0.0002206341,0.0001670454,0.0006872988,0.0003429884],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002042943,"about_ca_system_score_gemma":0.0002800635,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004100681,"about_ca_topic_score_gemma":0.0007939666,"domain_scores_codex":[0.9998001,0.0000274515,0.00003152353,0.00004006569,0.00004169381,0.00005919372],"domain_scores_gemma":[0.9998739,0.00002791353,0.00003144214,0.00001524491,0.00001604654,0.00003538197],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001515281,0.00006378777,0.00005279132,0.00004041283,0.000005501621,0.00001765001,0.00001123297,0.00002583586,0.998727,0.00003145284,0.00005039588,0.0008223639],"study_design_scores_gemma":[0.00005314371,0.00085273,0.002353807,0.000007885139,0.000027255,0.00008439482,0.00002234865,0.0008381217,0.9947036,0.00002021454,0.001032008,0.000004452963],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921359,0.001890475,0.003706181,0.0001685679,0.0000885168,0.00005436823,0.0003390036,0.0002049882,0.001412196],"genre_scores_gemma":[0.9892749,0.001672809,0.004447239,0.0001152732,0.00003800723,0.000159285,0.0007401909,0.00004756625,0.003504751],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001551133,"threshold_uncertainty_score":0.005189002,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02751392292102751,"score_gpt":0.3348348227236982,"score_spread":0.3073208998026707,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}