{"id":"W2071409339","doi":"10.1038/onc.2008.98","title":"DNA amplification is a ubiquitous mechanism of oncogene activation in lung and other cancers","year":2008,"lang":"en","type":"article","venue":"Oncogene","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":122,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Canadian Centre for Applied Research in Cancer Control; BC Cancer Agency","funders":"National Cancer Institute; Canadian Institutes of Health Research; Michael Smith Health Research BC","keywords":"Biology; Amplicon; Gene duplication; Carcinogenesis; Oncogene; Gene; Genetics; Cancer; Mechanism (biology); Chromosomal translocation; Cancer research; Polymerase chain reaction; Cell cycle","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007741007,0.00008457527,0.000100039,0.00004932266,0.00004534886,0.000003945826,0.00007338843,0.00009509943,0.0000284254],"category_scores_gemma":[0.00001066819,0.00008666814,0.00002940473,0.000105867,0.00004612339,0.000004182064,0.00002175857,0.00003246326,0.000001471042],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005625122,"about_ca_system_score_gemma":0.0001116868,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003189005,"about_ca_topic_score_gemma":0.00008641071,"domain_scores_codex":[0.9993854,0.00002245971,0.0001671722,0.0002291671,0.00008634597,0.0001095224],"domain_scores_gemma":[0.999588,0.00000417506,0.00009741366,0.0002275568,0.00004836834,0.00003448931],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003946989,0.00003077555,0.001172205,0.00001112961,0.00001774777,2.914689e-7,0.0002057486,0.00003013691,0.9949705,0.0002761464,0.000376729,0.002869117],"study_design_scores_gemma":[0.0004161638,0.00007090252,0.001852,0.00001279589,0.000007771654,0.000006343936,0.00006502452,0.0001707204,0.9873422,0.00008858248,0.00986137,0.0001061387],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932567,0.0005906674,0.004824767,0.0001130768,0.00004014423,0.0001548779,0.00002278462,0.000004521301,0.0009924936],"genre_scores_gemma":[0.9978464,0.0007256923,0.0005370198,0.0002986235,0.0000825828,0.0000498189,0.00002831584,0.00001526785,0.0004163124],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009484641,"threshold_uncertainty_score":0.3534224,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02054593290420173,"score_gpt":0.2705561224501201,"score_spread":0.2500101895459184,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}