{"id":"W2071426740","doi":"10.1359/jbmr.070701","title":"Alendronate Has an Anabolic Effect on Bone Through the Differentiation of Mesenchymal Stem Cells","year":2007,"lang":"en","type":"article","venue":"Journal of Bone and Mineral Research","topic":"Bone health and treatments","field":"Medicine","cited_by":160,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Merck","keywords":"Adipogenesis; Mesenchymal stem cell; Alkaline phosphatase; Osteoblast; Anabolism; Endocrinology; Internal medicine; Oil Red O; Stem cell; Cell biology; Cellular differentiation; Chemistry; In vitro; Biology; Biochemistry; Medicine; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002109116,0.0004113355,0.000379543,0.0004041699,0.0001883126,0.0004053854,0.0002596517,0.0003726762,0.001922953],"category_scores_gemma":[0.0001813902,0.0001321235,0.0005882078,0.0003761904,0.0003688076,0.0001541572,0.0002692388,0.0003914984,0.0005835454],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002102135,"about_ca_system_score_gemma":0.0003605685,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005023032,"about_ca_topic_score_gemma":0.001606329,"domain_scores_codex":[0.9997461,0.00004639506,0.00003441156,0.0000441052,0.00009332175,0.00003554031],"domain_scores_gemma":[0.9999125,0.00002010461,0.00002451648,0.00001056444,0.0000162925,0.00001591601],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004117709,0.00007904525,0.000744337,0.0002768982,0.00002240696,0.0001336427,0.00002248179,0.0001011816,0.9861895,0.0001571265,0.0001124124,0.0117491],"study_design_scores_gemma":[0.0001017706,0.001313826,0.007282531,0.00004630394,0.00009288132,0.0007445349,0.00005530114,0.0003932511,0.9729342,0.00009953893,0.01692573,0.00001010316],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9362268,0.04314704,0.01090893,0.0005870935,0.0002860016,0.0001450916,0.0008360136,0.0002924226,0.007570574],"genre_scores_gemma":[0.9733449,0.01078422,0.008625906,0.0002968716,0.00008550261,0.00008907159,0.0007847324,0.00002834227,0.005960608],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001922953,"threshold_uncertainty_score":0.00643295,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09198676313883182,"score_gpt":0.4073049001394337,"score_spread":0.3153181370006019,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}