{"id":"W2071445918","doi":"10.1073/pnas.170280397","title":"A cellular defense pathway regulating transcription through poly(ADP-ribosyl)ation in response to DNA damage","year":2000,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"","keywords":"Poly ADP ribose polymerase; Polymerase; Transcription (linguistics); DNA damage; RNA polymerase II; Biology; Molecular biology; DNA repair; RNA polymerase I; DNA; RNA polymerase; Cell biology; Biochemistry; RNA; RNA-dependent RNA polymerase; Gene expression; Gene; Promoter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001706194,0.0003991711,0.0002723373,0.0001720832,0.0001775355,0.0004091061,0.000179483,0.0004513788,0.00110772],"category_scores_gemma":[0.0001381591,0.0001001775,0.000230702,0.0001583969,0.0003877797,0.0002368363,0.0002323419,0.0006571036,0.0003485768],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002569893,"about_ca_system_score_gemma":0.0001519285,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009139171,"about_ca_topic_score_gemma":0.0001746172,"domain_scores_codex":[0.9998574,0.00002499564,0.00001039282,0.00005222697,0.00002965004,0.00002528351],"domain_scores_gemma":[0.9998448,0.0000300999,0.00004487717,0.0000317255,0.00001711609,0.00003130784],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004544948,0.00001343816,0.0001566597,0.00003638479,0.000002942205,0.00004126679,0.000007404515,0.0000579548,0.9964784,0.000173131,0.00002735229,0.002959601],"study_design_scores_gemma":[0.00001400991,0.0003487835,0.005634245,0.00001402802,0.000011649,0.0003265573,0.00002322761,0.0006811967,0.9872739,0.0004927728,0.005172488,0.000007152415],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8861951,0.03719556,0.06807996,0.001286416,0.000372595,0.0001289637,0.000564901,0.0006583767,0.005518146],"genre_scores_gemma":[0.9746787,0.006854703,0.01473782,0.0002725235,0.00008744038,0.00007068036,0.000540061,0.0000197293,0.00273831],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00110772,"threshold_uncertainty_score":0.00370568,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0529375136969971,"score_gpt":0.3262088370988653,"score_spread":0.2732713234018682,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}