{"id":"W2071492443","doi":"10.1371/journal.pgen.1003713","title":"Growth factor independent-1 Maintains Notch1-Dependent Transcriptional Programming of Lymphoid Precursors","year":2013,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"National Center for Advancing Translational Sciences; College of Medicine, University of Cincinnati; National Cancer Institute; National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases; Pelotonia; CancerFree KIDS; Canadian Institutes of Health Research; University of Cincinnati; Leukemia and Lymphoma Society; Alex's Lemonade Stand Foundation for Childhood Cancer","keywords":"Biology; Recombination-activating gene; Progenitor cell; Lymphopoiesis; Cell biology; Haematopoiesis; RAG2; Progenitor; T cell; Notch signaling pathway; Lineage (genetic); Cancer research; Genetics; Stem cell; Signal transduction; Gene; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006927136,0.0002434189,0.0001537801,0.0002561725,0.0001262733,0.0002850403,0.0002463275,0.0001569476,0.0007505217],"category_scores_gemma":[0.00009056174,0.0001095623,0.0001297108,0.00009424883,0.0001406321,0.0001283946,0.0002785348,0.0004610094,0.0004258251],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002839637,"about_ca_system_score_gemma":0.0001986818,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004739641,"about_ca_topic_score_gemma":0.0009128442,"domain_scores_codex":[0.9999138,0.000009040124,0.000008036764,0.00002156879,0.00002298536,0.00002452477],"domain_scores_gemma":[0.9998416,0.00001777846,0.00005197081,0.00002114712,0.0000146191,0.00005287373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003348618,0.000009099715,0.0001975673,0.000008461257,9.494164e-7,0.00003816111,0.00000823412,0.00003161872,0.998902,0.00007449895,0.00001527633,0.0006806717],"study_design_scores_gemma":[0.0000082803,0.0001030959,0.004621108,0.000005390083,0.000005994367,0.0002418465,0.0000186626,0.0006628839,0.9919893,0.00006293505,0.002277652,0.000002761563],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955928,0.0006861031,0.001499787,0.00003613543,0.000007127862,0.00001700043,0.0006408262,0.0001078499,0.001412477],"genre_scores_gemma":[0.993944,0.0003606061,0.001472114,0.00003408936,0.000005469115,0.00002680547,0.001110896,0.00004167989,0.003004413],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007505217,"threshold_uncertainty_score":0.002510726,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01584222784275158,"score_gpt":0.2296929418095097,"score_spread":0.2138507139667581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}