{"id":"W2071492443","doi":"10.1371/journal.pgen.1003713","title":"Growth factor independent-1 Maintains Notch1-Dependent Transcriptional Programming of Lymphoid Precursors","year":2013,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"National Center for Advancing Translational Sciences; College of Medicine, University of Cincinnati; National Cancer Institute; National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases; Pelotonia; CancerFree KIDS; Canadian Institutes of Health Research; University of Cincinnati; Leukemia and Lymphoma Society; Alex's Lemonade Stand Foundation for Childhood Cancer","keywords":"Biology; Recombination-activating gene; Progenitor cell; Lymphopoiesis; Cell biology; Haematopoiesis; RAG2; Progenitor; T cell; Notch signaling pathway; Lineage (genetic); Cancer research; Genetics; Stem cell; Signal transduction; Gene; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005117228,0.0001655112,0.0001404249,0.00005163333,0.00005993089,0.00003476148,0.0002676754,0.0001545851,0.0002068089],"category_scores_gemma":[0.00002180505,0.0001609365,0.0001030678,0.00007893141,0.00008575663,0.000006270869,0.00005291158,0.00007336248,0.0000271847],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003069864,"about_ca_system_score_gemma":0.0001141235,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002706568,"about_ca_topic_score_gemma":0.00002623883,"domain_scores_codex":[0.9987943,0.00003917564,0.0002880112,0.0003192911,0.0002905136,0.0002687423],"domain_scores_gemma":[0.9991834,0.000006533303,0.0001092037,0.0003259095,0.0002648279,0.0001101702],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001948185,0.000250545,0.01392945,0.00004084788,0.0001028002,4.343666e-7,0.0001361037,0.00006639968,0.9800768,0.0002074734,0.0001448264,0.00502486],"study_design_scores_gemma":[0.0006579274,0.0002728166,0.01200244,0.00001607271,0.00004304191,0.00001014146,0.0002200145,0.0003383077,0.9822863,0.0002205285,0.003654316,0.0002781144],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954243,0.001001654,0.002329851,0.0001078303,0.0001079524,0.0004688409,0.00007887928,0.00001458908,0.0004661242],"genre_scores_gemma":[0.9967301,0.0003834513,0.001887008,0.00008727107,0.0001508722,0.0001611672,0.00009537111,0.00003202487,0.0004726676],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004746746,"threshold_uncertainty_score":0.65628,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01584222784275158,"score_gpt":0.2296929418095097,"score_spread":0.2138507139667581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}