{"id":"W2071498240","doi":"10.1210/endo.142.2.7958","title":"Relative Enzymatic Activity, Protein Stability, and Tissue Distribution of Human Steroid-Metabolizing UGT2B Subfamily Members**This work was supported by the Medical Research Council of Canada, the Fonds de la Recherche en Sante du Quebec, and Endorecherche.","year":2001,"lang":"en","type":"article","venue":"Endocrinology","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":330,"is_retracted":false,"has_abstract":true,"ca_institutions":"Medical Council of Canada; Université Laval","funders":"","keywords":"Glucuronidation; Steroid; UGT2B7; Chemistry; Hydroxysteroid; Farnesoid X receptor; Enzyme; Biochemistry; Biology; Hormone; Nuclear receptor; Transcription factor; Microsome; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["research_integrity"],"consensus_categories":[],"category_scores_codex":[0.01719151,0.0002531671,0.0005009124,0.0000591562,0.0004228029,0.00001932601,0.0005244572,0.0005981423,0.0007093032],"category_scores_gemma":[0.005990925,0.0001791872,0.00005175977,0.0004415795,0.002094315,0.00007955961,0.0004426044,0.003195833,0.000001329798],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008221471,"about_ca_system_score_gemma":0.002887129,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.1115436,"about_ca_topic_score_gemma":0.08396043,"domain_scores_codex":[0.9798205,0.01762648,0.0005443758,0.0003919456,0.000819459,0.0007972272],"domain_scores_gemma":[0.986587,0.01215497,0.0002314642,0.0003176673,0.0004663983,0.0002424761],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009771497,0.0006465687,0.02215845,0.0002027663,0.00071529,0.0001776817,0.01571582,0.000008529262,0.8768616,0.01176338,0.01524159,0.05553118],"study_design_scores_gemma":[0.003298315,0.0002100071,0.02676914,0.00005201349,0.0003296705,0.0002889775,0.00184325,0.0005856992,0.7092216,0.00687176,0.2501988,0.0003307396],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9796519,0.00684526,0.0001021755,0.006988472,0.0001460132,0.000801585,0.0001223319,0.00001918585,0.005323133],"genre_scores_gemma":[0.9953591,0.002963447,0.00005309139,0.0002415648,0.0000956876,0.0001350509,0.00001568973,0.00002299379,0.00111335],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2349572,"threshold_uncertainty_score":0.9991038,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3656745773689246,"score_gpt":0.4818970356491107,"score_spread":0.1162224582801862,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}