{"id":"W2071498240","doi":"10.1210/endo.142.2.7958","title":"Relative Enzymatic Activity, Protein Stability, and Tissue Distribution of Human Steroid-Metabolizing UGT2B Subfamily Members**This work was supported by the Medical Research Council of Canada, the Fonds de la Recherche en Sante du Quebec, and Endorecherche.","year":2001,"lang":"en","type":"article","venue":"Endocrinology","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":330,"is_retracted":false,"has_abstract":true,"ca_institutions":"Medical Council of Canada; Université Laval","funders":"","keywords":"Glucuronidation; Steroid; UGT2B7; Chemistry; Hydroxysteroid; Farnesoid X receptor; Enzyme; Biochemistry; Biology; Hormone; Nuclear receptor; Transcription factor; Microsome; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002731067,0.000544976,0.0003624774,0.000842933,0.0002885781,0.0007111371,0.0001666518,0.0003495382,0.002374229],"category_scores_gemma":[0.0005447418,0.000166383,0.0004553024,0.00101512,0.0002085677,0.0002053262,0.0002098675,0.0003732876,0.001450502],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004589934,"about_ca_system_score_gemma":0.0002532727,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004964661,"about_ca_topic_score_gemma":0.002713687,"domain_scores_codex":[0.9996938,0.00003403015,0.00002550377,0.0001167243,0.00006827845,0.00006174883],"domain_scores_gemma":[0.9997857,0.00003188937,0.00003684845,0.00002598954,0.00007433942,0.00004525975],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001947958,0.0001280365,0.02551194,0.0002613375,0.0002829953,0.0003857259,0.000182499,0.0003021619,0.9335552,0.0003745096,0.002491944,0.03457568],"study_design_scores_gemma":[0.0001303687,0.0007988816,0.4218885,0.00004463061,0.0003826226,0.006093879,0.0002265527,0.005682677,0.5028629,0.0003296589,0.0614999,0.00005945844],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.951667,0.02361964,0.008784419,0.0004387129,0.0001660086,0.00009349534,0.01050982,0.0002215851,0.004499366],"genre_scores_gemma":[0.9351588,0.006383602,0.007660761,0.0002278563,0.000123678,0.000152032,0.03803086,0.0001476952,0.01211485],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004964661,"threshold_uncertainty_score":0.009871483,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3656745773689246,"score_gpt":0.4818970356491107,"score_spread":0.1162224582801862,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}