{"id":"W2071500438","doi":"10.1074/jbc.m604753200","title":"Helix Packing of the Cardiac Na+-Ca2+ Exchanger","year":2006,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Insect Resistance and Genetics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"Intracellular; Cysteine; Transmembrane domain; Transmembrane protein; Biology; Cell biology; Contractility; Mutant; Biophysics; Sodium-calcium exchanger; Helix (gastropod); Biochemistry; Membrane; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000207324,0.0001141367,0.0002007932,0.000008431817,0.00004477444,0.00000873277,0.0002752297,0.0002217915,0.00003366024],"category_scores_gemma":[0.00008651107,0.00006651244,0.0003098329,0.00007154323,0.0001371623,0.000001584842,0.0000868925,0.0001459823,7.945093e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001332775,"about_ca_system_score_gemma":0.00005647275,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003440755,"about_ca_topic_score_gemma":0.000001173434,"domain_scores_codex":[0.999182,0.00004180017,0.0003326905,0.000120825,0.0001537634,0.0001689256],"domain_scores_gemma":[0.9992447,0.00001630927,0.0003236718,0.0002091245,0.0001678673,0.00003831868],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005632354,0.00004312473,0.01993383,0.00002405229,0.00003124116,0.000002909587,0.000005201482,0.00002167498,0.9779506,0.000005522691,0.001562935,0.0003625703],"study_design_scores_gemma":[0.000184303,0.00009776468,0.02360548,0.00002780099,0.00001704857,0.00002816139,0.00003175047,7.8203e-7,0.9605782,0.0001289897,0.01521078,0.00008893946],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938654,0.003992849,0.00007273469,0.00009289375,0.0001509696,0.00003892123,0.00001519968,0.000001894744,0.001769171],"genre_scores_gemma":[0.9979703,0.0003460257,0.0002096245,0.00008170225,0.0008521256,0.000001320939,0.000008922445,0.000006999157,0.0005229707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01737241,"threshold_uncertainty_score":0.2712298,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0109403854790444,"score_gpt":0.2287017261278983,"score_spread":0.2177613406488539,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}