{"id":"W2071539936","doi":"10.1097/jto.0b013e3182773fce","title":"Symptom and Quality of Life Benefit of Afatinib in Advanced Non–Small-Cell Lung Cancer Patients Previously Treated with Erlotinib or Gefitinib: Results of a Randomized Phase IIb/III Trial (LUX-Lung 1)","year":2013,"lang":"en","type":"article","venue":"Journal of Thoracic Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":78,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; McGill University Health Centre","funders":"","keywords":"Medicine; Afatinib; Lung cancer; Placebo; Internal medicine; Gefitinib; Erlotinib; Adverse effect; Quality of life (healthcare); Randomized controlled trial; Chest pain; Gastroenterology; Cancer; Pathology; Epidermal growth factor receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001231899,0.001339272,0.002615268,0.0002813433,0.0004328241,0.001166901,0.0007116273,0.001317021,0.003379094],"category_scores_gemma":[0.001126349,0.0004386755,0.002813353,0.0003912663,0.001111111,0.001062432,0.0003901346,0.002860161,0.000540967],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009691789,"about_ca_system_score_gemma":0.0008054712,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001269607,"about_ca_topic_score_gemma":0.004045354,"domain_scores_codex":[0.9994649,0.0002455846,0.00003812196,0.0001061784,0.00003495566,0.0001102416],"domain_scores_gemma":[0.9993874,0.0001359548,0.0001463617,0.00003954981,0.00002986504,0.0002608013],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9400766,0.004628352,0.005837761,0.0006997573,0.002560053,0.00008418485,0.00008978522,0.001112022,0.006168674,0.0001445035,0.002016556,0.03658176],"study_design_scores_gemma":[0.9025398,0.07579102,0.01755224,0.00003332061,0.001454742,0.000134171,0.00006222842,0.0006969692,0.0005870443,0.0002186957,0.0008971868,0.00003254092],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938383,0.003016644,0.0001411128,0.0006726251,0.0001600205,0.0003613998,0.0007237566,0.00004883063,0.001037357],"genre_scores_gemma":[0.9955153,0.001146472,0.0003505938,0.0005313706,0.0001881213,0.0003850042,0.001150864,0.00001110668,0.0007212192],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003379094,"threshold_uncertainty_score":0.01130426,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02487591600355954,"score_gpt":0.4309749554100554,"score_spread":0.4060990394064959,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}