{"id":"W2071591126","doi":"10.1038/srep07281","title":"Activation of NLRP3 inflammasome by crystalline structures via cell surface contact","year":2014,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":107,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; University of Calgary","keywords":"Inflammasome; Chemistry; Cell biology; Cathepsin B; Biophysics; Pyroptosis; Cathepsin; Caspase 1; Efflux; Phagolysosome; Biochemistry; Macrophage; Biology; Receptor; Enzyme; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005174918,0.0001346075,0.0001497525,0.00004061611,0.0001128265,0.00004931269,0.0001259267,0.0001147251,0.00005747515],"category_scores_gemma":[0.00009113577,0.00012388,0.00008719293,0.0001240359,0.00009774434,0.00001210671,0.00006378545,0.0000612896,0.000003153477],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008069745,"about_ca_system_score_gemma":0.00006174689,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002804569,"about_ca_topic_score_gemma":0.000006605376,"domain_scores_codex":[0.998685,0.00004545036,0.0003919072,0.0004346681,0.0002319221,0.0002110296],"domain_scores_gemma":[0.9987862,0.000008073202,0.0003462038,0.0006336993,0.0001774254,0.00004839393],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002127356,0.00003035513,0.001981275,0.00002305533,0.00001364883,0.000001292559,0.00004574595,0.0004343613,0.9896019,0.00001488704,0.007216863,0.000615342],"study_design_scores_gemma":[0.0001890563,0.00008362985,0.0006785756,0.00000562233,0.000007282834,0.000006657868,0.00003281706,0.00007772863,0.8835994,0.0006822913,0.1145044,0.0001325961],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934185,0.0002018302,0.003647319,0.00003258732,0.0007798259,0.0001604771,0.000003239735,0.00001076612,0.001745514],"genre_scores_gemma":[0.9958097,0.0000083654,0.0002491774,0.00002999906,0.00004475748,0.000002988554,0.0005649516,0.00001535743,0.003274717],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1072875,"threshold_uncertainty_score":0.5051678,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00317331710307073,"score_gpt":0.2002457536230088,"score_spread":0.1970724365199381,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}