{"id":"W2071591126","doi":"10.1038/srep07281","title":"Activation of NLRP3 inflammasome by crystalline structures via cell surface contact","year":2014,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":107,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; University of Calgary","keywords":"Inflammasome; Chemistry; Cell biology; Cathepsin B; Biophysics; Pyroptosis; Cathepsin; Caspase 1; Efflux; Phagolysosome; Biochemistry; Macrophage; Biology; Receptor; Enzyme; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001177422,0.000196005,0.000275738,0.0001172657,0.0001926152,0.0004709371,0.0001383725,0.0004305585,0.001824174],"category_scores_gemma":[0.0002137082,0.0001265354,0.0003242964,0.0001515499,0.0002988295,0.0003206331,0.000376581,0.0002854567,0.0003903431],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000278972,"about_ca_system_score_gemma":0.0002547452,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004623836,"about_ca_topic_score_gemma":0.0006485883,"domain_scores_codex":[0.9997994,0.00003769827,0.00001705758,0.00003751372,0.00007085562,0.00003749305],"domain_scores_gemma":[0.9998825,0.00003211624,0.00002842632,0.00002190125,0.00002215229,0.00001298718],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001005962,0.0000151302,0.0005105915,0.00006875016,0.00001152915,0.0002309683,0.00003061058,0.00005933562,0.9976302,0.0003036013,0.00008360525,0.0009549413],"study_design_scores_gemma":[0.00003390829,0.0002208222,0.006293037,0.00001343719,0.00001805842,0.0007058943,0.0001111753,0.001456896,0.987324,0.0003710822,0.003441343,0.00001031212],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903122,0.002199652,0.003949907,0.0001557219,0.00004322126,0.0000275775,0.0002047183,0.00003783595,0.003069201],"genre_scores_gemma":[0.9966534,0.0007094263,0.001141546,0.00004139474,0.00001228852,0.00001871997,0.0001683519,0.000006239356,0.001248711],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001824174,"threshold_uncertainty_score":0.006102443,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00317331710307073,"score_gpt":0.2002457536230088,"score_spread":0.1970724365199381,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}