{"id":"W2071607258","doi":"10.1007/s002800000228","title":"A review of dose-limiting events in phase I trials: antimetabolites show unpredictable relationships between dose and toxicity","year":2000,"lang":"en","type":"review","venue":"Cancer Chemotherapy and Pharmacology","topic":"Statistical Methods in Clinical Trials","field":"Mathematics","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"National Cancer Institute","keywords":"Toxicity; Maximum tolerated dose; Limiting; Pharmacology; Medicine; Oncology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005407964,0.001145705,0.005260456,0.00245241,0.0001723433,0.001238451,0.0009787024,0.0008536205,0.002104448],"category_scores_gemma":[0.01562058,0.0004689242,0.001838152,0.004154861,0.0006200534,0.001185411,0.0004755623,0.001255412,0.0006230747],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001060574,"about_ca_system_score_gemma":0.002602439,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009304646,"about_ca_topic_score_gemma":0.002598354,"domain_scores_codex":[0.9972065,0.00117885,0.0007135883,0.0001919068,0.0006672131,0.00004185205],"domain_scores_gemma":[0.9862088,0.01100948,0.001785178,0.0001795114,0.0007328793,0.00008413154],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"systematic_review","study_design_scores_codex":[0.0002820582,0.0000330322,0.0002099584,0.1210028,0.001042441,0.00005282861,0.00004055876,0.0009120018,0.0003953507,0.001784965,0.0138084,0.8604357],"study_design_scores_gemma":[0.00125319,0.001493178,0.006385588,0.1467057,0.01804996,0.003077362,0.0001567451,0.001837917,0.002106577,0.01413125,0.8046558,0.000146818],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001437718,0.998188,0.0009960074,0.0002961809,0.0001003588,0.00002789526,0.00004028561,0.00001382883,0.0001938125],"genre_scores_gemma":[0.001804307,0.995994,0.001472295,0.000378121,0.0001427411,0.0000557238,0.00003311904,0.000006247234,0.0001135281],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005407964,"threshold_uncertainty_score":0.02860034,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.7038922919024159,"score_gpt":0.6398705854915662,"score_spread":0.0640217064108497,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}