{"id":"W2071621051","doi":"10.1310/hag3-8ya5-udqc-36nx","title":"Virologic and Immunologic Response to a Boosted Double-Protease Inhibitor-Based Therapy in Highly Pretreated HIV-1-Infected Patients","year":2005,"lang":"en","type":"article","venue":"HIV Clinical Trials","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Victoria Hospital; Royal Victoria Regional Health Centre; McGill University Health Centre","funders":"Canadian Institutes of Health Research; Abbott Canada; Abbott Laboratories","keywords":"Saquinavir; Medicine; Lopinavir; Regimen; Protease inhibitor (pharmacology); Internal medicine; Ritonavir; Viral load; Lamivudine; Gastroenterology; Immunology; Odds ratio; Reverse-transcriptase inhibitor; Nelfinavir; Drug resistance; Pharmacology; Virology; Virus; Antiretroviral therapy; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004548088,0.0002461418,0.0003660928,0.00009900496,0.0001725638,0.0002564621,0.0001162406,0.0002803366,0.0008579175],"category_scores_gemma":[0.001198635,0.0001410952,0.0002033455,0.00008552198,0.000213961,0.0001641363,0.0001327234,0.0004154649,0.0001061603],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001691989,"about_ca_system_score_gemma":0.0001846611,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001984452,"about_ca_topic_score_gemma":0.0003487766,"domain_scores_codex":[0.9997728,0.0001104572,0.00002285605,0.00003366112,0.00002974998,0.00003036204],"domain_scores_gemma":[0.9992679,0.0002199881,0.000241047,0.00003383141,0.00003305326,0.0002041519],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.02974271,0.002016963,0.8784977,0.0002081305,0.0003032075,0.0008879478,0.0002511908,0.001009922,0.03751842,0.00006491165,0.0004399942,0.04905885],"study_design_scores_gemma":[0.001923323,0.04447665,0.943252,0.00003217189,0.0001434657,0.002679296,0.0001144974,0.001569511,0.005001983,0.00004648446,0.0007418416,0.00001884925],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995541,0.0002386435,0.00004673899,0.00001782913,0.000003032066,0.00001110122,0.00001849888,0.000002656605,0.0001075293],"genre_scores_gemma":[0.9995849,0.00005921665,0.000157174,0.00004823899,0.00001507975,0.000009350279,0.00006714677,7.502152e-7,0.00005798121],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008579175,"threshold_uncertainty_score":0.002870023,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1259546533319276,"score_gpt":0.4069000041686832,"score_spread":0.2809453508367556,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}