{"id":"W2071621051","doi":"10.1310/hag3-8ya5-udqc-36nx","title":"Virologic and Immunologic Response to a Boosted Double-Protease Inhibitor-Based Therapy in Highly Pretreated HIV-1-Infected Patients","year":2005,"lang":"en","type":"article","venue":"HIV Clinical Trials","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Victoria Hospital; Royal Victoria Regional Health Centre; McGill University Health Centre","funders":"Canadian Institutes of Health Research; Abbott Canada; Abbott Laboratories","keywords":"Saquinavir; Medicine; Lopinavir; Regimen; Protease inhibitor (pharmacology); Internal medicine; Ritonavir; Viral load; Lamivudine; Gastroenterology; Immunology; Odds ratio; Reverse-transcriptase inhibitor; Nelfinavir; Drug resistance; Pharmacology; Virology; Virus; Antiretroviral therapy; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.006143239,0.0004120853,0.001576063,0.0004274724,0.00008638183,0.00004173346,0.0001248339,0.0004485641,0.0003128786],"category_scores_gemma":[0.008033012,0.0002774453,0.0002880787,0.0005751186,0.000132807,0.00008405837,0.00007197527,0.0003916694,0.0005326293],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00019067,"about_ca_system_score_gemma":0.0002764937,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001006911,"about_ca_topic_score_gemma":0.000007338472,"domain_scores_codex":[0.9933051,0.002956181,0.002151899,0.0007571513,0.000346837,0.0004828473],"domain_scores_gemma":[0.9944987,0.004041793,0.0003968761,0.0005015405,0.0001624076,0.0003987001],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.2268108,0.005721848,0.721313,0.00002091241,0.0003612838,0.000188711,0.0002787813,0.00001645974,0.005094424,0.000008796261,0.005596448,0.03458856],"study_design_scores_gemma":[0.1412928,0.005586782,0.8178546,0.0003092711,0.0001860229,0.000004084556,0.00002409316,0.0001324938,0.009393724,0.00002315534,0.02471732,0.0004756509],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.980963,0.000255563,0.00001342057,0.01390066,0.0001590207,0.004264613,0.00005042668,0.0002042868,0.00018899],"genre_scores_gemma":[0.9932051,0.0001623308,0.001670003,0.001603598,0.0001837668,0.000388158,0.0001837233,0.00003632733,0.00256699],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09654162,"threshold_uncertainty_score":0.9999678,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1259546533319276,"score_gpt":0.4069000041686832,"score_spread":0.2809453508367556,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}