{"id":"W2071621125","doi":"10.1111/cbdd.12278","title":"Homology and Molecular Dynamics Models of Toll‐Like Receptor 7 Protein and Its Dimerization","year":2014,"lang":"en","type":"article","venue":"Chemical Biology & Drug Design","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Kommission für Technologie und Innovation","keywords":"Homology modeling; Docking (animal); Transmembrane protein; Receptor; G protein-coupled receptor; Toll-like receptor; Computational biology; Transmembrane domain; Innate immune system; Dimer; Chemistry; Protein structure; Protein–protein interaction; Biology; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000204496,0.0004595271,0.0006206193,0.0003867124,0.0008309445,0.0006052087,0.0008725725,0.0009909387,0.003421927],"category_scores_gemma":[0.000435778,0.0003241381,0.0005975025,0.0004712694,0.0004508338,0.0006353054,0.0003998013,0.0005490509,0.0004329188],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001179349,"about_ca_system_score_gemma":0.0009636263,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01186249,"about_ca_topic_score_gemma":0.003754928,"domain_scores_codex":[0.9998792,0.00003711426,0.000005522327,0.00001930804,0.00002841804,0.0000304645],"domain_scores_gemma":[0.9998259,0.0000753819,0.00002211311,0.00001313259,0.00002692928,0.00003646878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00008536394,0.00008398024,0.0004758867,0.00003379355,0.00001966824,0.0001362548,0.00006124995,0.9822895,0.003814027,0.01131343,0.0004504856,0.001236382],"study_design_scores_gemma":[0.00004323102,0.00002415936,0.0001788294,0.000003268891,0.000003696121,0.00001012326,0.00001402604,0.997008,0.0003177235,0.001760722,0.0006306003,0.000005677613],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9038993,0.00131568,0.0577799,0.001217971,0.0001060096,0.0001187797,0.001349841,0.000366443,0.03384602],"genre_scores_gemma":[0.9794111,0.0008028653,0.01359434,0.0001361778,0.00002936611,0.000265402,0.001117261,0.00007595994,0.00456747],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01186249,"threshold_uncertainty_score":0.02358687,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007432775407711608,"score_gpt":0.202132397520347,"score_spread":0.1946996221126354,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}