{"id":"W2071632391","doi":"10.1002/cbic.200500538","title":"Aptamer to Ribozyme: The Intrinsic Catalytic Potential of a Small RNA","year":2006,"lang":"en","type":"article","venue":"ChemBioChem","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"National Science Foundation","keywords":"Ribozyme; Aptamer; Ligase ribozyme; RNA; Catalysis; Chemistry; Folding (DSP implementation); Substrate (aquarium); Hairpin ribozyme; Nucleic acid structure; Combinatorial chemistry; Nanotechnology; Biology; Biochemistry; Materials science; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001705784,0.0001550309,0.0001498366,0.00002929501,0.00005871509,0.00001802352,0.0003395865,0.0001287287,0.00002807082],"category_scores_gemma":[0.00005699402,0.0001192863,0.0001282509,0.0001170511,0.00007479393,0.000001499021,0.0001512048,0.00005808946,0.00003849959],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009553734,"about_ca_system_score_gemma":0.00004670723,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009212071,"about_ca_topic_score_gemma":0.00001779302,"domain_scores_codex":[0.9991016,0.00002618719,0.0002169769,0.0002911706,0.0001264793,0.0002375911],"domain_scores_gemma":[0.9992504,0.000009453578,0.00008614329,0.0005170497,0.00007710979,0.00005987105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005002918,0.0000472675,0.0000221089,0.00001588805,0.00002649762,0.000001968866,0.00001704453,0.00001163193,0.9935279,0.000241764,0.001886125,0.004151777],"study_design_scores_gemma":[0.0002248052,0.0000928205,0.0003955787,0.00001210806,0.00002719273,0.00001166555,0.0000377699,0.000007244097,0.9920065,0.0002772646,0.006751621,0.000155433],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914842,0.0006530673,0.003960007,0.0004395867,0.0001286373,0.0002674033,0.00001317176,0.00001200564,0.0030419],"genre_scores_gemma":[0.9959605,0.00001637416,0.0009693709,0.000248877,0.0003840558,0.00003956246,0.00004920254,0.00002436422,0.002307697],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004865496,"threshold_uncertainty_score":0.4864355,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006912941465015319,"score_gpt":0.2022824028960774,"score_spread":0.195369461431062,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}