{"id":"W2071632391","doi":"10.1002/cbic.200500538","title":"Aptamer to Ribozyme: The Intrinsic Catalytic Potential of a Small RNA","year":2006,"lang":"en","type":"article","venue":"ChemBioChem","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"National Science Foundation","keywords":"Ribozyme; Aptamer; Ligase ribozyme; RNA; Catalysis; Chemistry; Folding (DSP implementation); Substrate (aquarium); Hairpin ribozyme; Nucleic acid structure; Combinatorial chemistry; Nanotechnology; Biology; Biochemistry; Materials science; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002831654,0.0003336389,0.0003903277,0.0001949683,0.0002222298,0.0006754066,0.0002757674,0.0006166183,0.00186615],"category_scores_gemma":[0.0006034712,0.0001514977,0.0002460041,0.0001400159,0.0007756959,0.0005520912,0.0005020851,0.0009272621,0.001077139],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002684473,"about_ca_system_score_gemma":0.0001671893,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007308055,"about_ca_topic_score_gemma":0.00005866574,"domain_scores_codex":[0.9997993,0.00005120021,0.000009825322,0.00006138367,0.00005239514,0.00002596678],"domain_scores_gemma":[0.9997603,0.0001058298,0.00003864194,0.00002213132,0.00001769359,0.00005541842],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001066346,0.00003386938,0.0002957932,0.0002005532,0.00001635001,0.0006236483,0.00006977277,0.0006880345,0.9637932,0.01965542,0.0003862672,0.01413054],"study_design_scores_gemma":[0.00003191695,0.000390757,0.0007038554,0.0000180814,0.00002038349,0.001775038,0.00002199636,0.002969282,0.9666539,0.007041981,0.02035516,0.00001755964],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7538839,0.02788923,0.1807179,0.003876073,0.001238657,0.0001772899,0.0002721553,0.001878875,0.03006585],"genre_scores_gemma":[0.9614296,0.00345896,0.02392344,0.00110726,0.0002472884,0.00006405862,0.0001298804,0.0001378034,0.009501632],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00186615,"threshold_uncertainty_score":0.006242931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006912941465015319,"score_gpt":0.2022824028960774,"score_spread":0.195369461431062,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}