{"id":"W2071639116","doi":"10.1016/j.bpj.2015.02.001","title":"Probing the Huntingtin 1-17 Membrane Anchor on a Phospholipid Bilayer by Using All-Atom Simulations","year":2015,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":38,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"Compute Canada","keywords":"POPC; Huntingtin; Chemistry; Bilayer; Membrane; Lipid bilayer; Molecular dynamics; Huntingtin Protein; Biophysics; Crystallography; Computational chemistry; Biochemistry; Mutant; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001213398,0.0002079433,0.0001732878,0.00005528679,0.0004920054,0.0002957153,0.0003801259,0.00003810418,0.00004435889],"category_scores_gemma":[0.0003625632,0.0001366418,0.0001250879,0.0003252993,0.0001462637,0.000169233,0.00008571045,0.0003715396,0.00005199515],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000049586,"about_ca_system_score_gemma":0.0001126562,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004388832,"about_ca_topic_score_gemma":2.798521e-7,"domain_scores_codex":[0.9980758,0.0002998771,0.0002772611,0.0003578975,0.000597035,0.0003920645],"domain_scores_gemma":[0.9989018,0.0002393614,0.0001932292,0.0002699818,0.00008015231,0.0003154602],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004874909,0.0002362261,0.00005120636,0.000001844813,0.000006673077,0.00001050851,0.0001862699,0.01229867,0.984683,0.0001496673,0.002125735,0.0002014731],"study_design_scores_gemma":[0.0005025265,0.0001203352,0.00007126069,0.00001884338,0.00003184049,0.00003543215,0.00004360639,0.01788954,0.9761726,0.00009551505,0.004847228,0.0001713051],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973643,0.00001357461,0.000405547,0.001325226,0.0003884575,0.0002206665,0.00003242581,0.00003534409,0.0002144283],"genre_scores_gemma":[0.9957724,0.000004197903,0.0001666114,0.003135111,0.0007156759,0.000005267789,0.000001594722,0.00003278547,0.0001663178],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00851041,"threshold_uncertainty_score":0.5572089,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08189865119082983,"score_gpt":0.3159446658876474,"score_spread":0.2340460146968176,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}