{"id":"W2071682241","doi":"10.1016/j.bbamem.2007.06.023","title":"The relationship between the binding to and permeabilization of phospholipid bilayer membranes by GS14dK4, a designed analog of the antimicrobial peptide gramicidin S","year":2007,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Biomembranes","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary; University of Alberta","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences","keywords":"Phospholipid; Membrane; Chemistry; Vesicle; Gramicidin; Gramicidin S; Peptide; Isothermal titration calorimetry; Lipid bilayer; Bilayer; POPC; Biophysics; Liposome; Biochemistry; Antimicrobial peptides; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002089054,0.000263281,0.0001761371,0.0001340208,0.0001647381,0.0003789259,0.0002670369,0.0003572881,0.002686654],"category_scores_gemma":[0.0005430399,0.0002695547,0.0001583273,0.00009902262,0.0003347218,0.0005824607,0.0002695704,0.0005541106,0.0006183762],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005670094,"about_ca_system_score_gemma":0.0001612631,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005005405,"about_ca_topic_score_gemma":0.000404875,"domain_scores_codex":[0.9998308,0.0000371601,0.00001470136,0.00003186035,0.00002919833,0.00005626843],"domain_scores_gemma":[0.9996656,0.0001483659,0.00006915425,0.0000247664,0.00003669807,0.00005539969],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003845334,0.00002250797,0.0001646311,0.00002575239,0.000005293618,0.00003751241,0.00002328037,0.0002023881,0.9981194,0.0002475843,0.00004498447,0.0007221582],"study_design_scores_gemma":[0.00001124391,0.0001181816,0.002120525,0.000002465098,0.0000037747,0.00008038143,0.00002696768,0.001639781,0.9953548,0.0000626789,0.0005752153,0.000004019754],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967886,0.0004577148,0.001272211,0.00009135433,0.00001498595,0.00001243179,0.0001129879,0.00002984271,0.001219837],"genre_scores_gemma":[0.9971112,0.0002017655,0.0004905278,0.00005690233,0.000003982142,0.00001536173,0.0002337503,0.000009586191,0.00187684],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002686654,"threshold_uncertainty_score":0.008987725,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01748181635742617,"score_gpt":0.2532348268686977,"score_spread":0.2357530105112715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}