{"id":"W2071683275","doi":"10.1097/01.qai.0000137005.63376.6e","title":"Resistance Issues With New Nucleoside/Nucleotide Backbone Options","year":2004,"lang":"en","type":"article","venue":"JAIDS Journal of Acquired Immune Deficiency Syndromes","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"","keywords":"Resistance mutation; Abacavir; Zidovudine; Stavudine; Medicine; Emtricitabine; Lamivudine; Drug resistance; Clinical trial; Nucleoside Reverse Transcriptase Inhibitor; Virology; Nucleoside; Reverse transcriptase; Internal medicine; Pharmacology; Biology; Human immunodeficiency virus (HIV); Antiretroviral therapy; Genetics; Viral load; Virus; Viral disease; Polymerase chain reaction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005081693,0.0003506849,0.0008555395,0.0006111441,0.0002323019,0.00007820824,0.0002977998,0.00009677021,0.0001886958],"category_scores_gemma":[0.0002478555,0.0002471094,0.0002990833,0.001081626,0.0002037354,0.0004925284,0.00005036588,0.0001645962,0.0002990923],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003022954,"about_ca_system_score_gemma":0.0009479497,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004137269,"about_ca_topic_score_gemma":0.0000195665,"domain_scores_codex":[0.9972813,0.00004101317,0.001005516,0.0002953825,0.0008599729,0.0005168305],"domain_scores_gemma":[0.9982082,0.00007919856,0.0005242003,0.0004618225,0.0003438091,0.0003827913],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0212576,0.02698775,0.1912744,0.003381065,0.01836251,0.05635152,0.07870444,0.006112704,0.243458,0.07329368,0.2422146,0.03860174],"study_design_scores_gemma":[0.063691,0.01158455,0.6777911,0.0163285,0.004898352,0.03108541,0.01502418,0.00002944654,0.07446828,0.0171587,0.08440484,0.003535647],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9576134,0.01646961,0.0007837168,0.02237298,0.000334566,0.0003604802,0.000005155232,0.0001197286,0.001940358],"genre_scores_gemma":[0.9043801,0.001936023,0.05170843,0.0001281263,0.0001183232,0.000006412378,0.00001148981,0.00008259858,0.04162847],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4865167,"threshold_uncertainty_score":0.9999981,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01552054243376064,"score_gpt":0.2637781314582683,"score_spread":0.2482575890245076,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}