{"id":"W2071692019","doi":"10.1159/000335850","title":"Curcumin Blocks Kv11.1 (<i>erg</i>) Potassium Current and Slows Proliferation in the Infant Acute Monocytic Leukemia Cell line THP-1","year":2011,"lang":"en","type":"article","venue":"Cellular Physiology and Biochemistry","topic":"Curcumin's Biomedical Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"THP1 cell line; Cell growth; Curcumin; Myeloid leukemia; Cell culture; Leukemia; Potassium channel; Cell biology; Monocytic leukemia; Haematopoiesis; Intracellular; Cancer research; Chemistry; Stem cell; Biology; Medicine; Pharmacology; Immunology; Internal medicine; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009156758,0.0002798991,0.0002092598,0.0001381182,0.0001515437,0.0001601129,0.000145841,0.0001459675,0.001821108],"category_scores_gemma":[0.00010614,0.0001212059,0.0001553142,0.00007400521,0.0001785746,0.0001494064,0.0001123088,0.0005287933,0.0004321832],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002738955,"about_ca_system_score_gemma":0.0002538476,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009724717,"about_ca_topic_score_gemma":0.001709447,"domain_scores_codex":[0.9999411,0.00001599135,0.000006511038,0.000007830544,0.00001092789,0.00001759658],"domain_scores_gemma":[0.9999558,0.00001318071,0.000007831682,0.00000629258,0.000007309481,0.000009661756],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002954654,0.00005594335,0.00008648733,0.000100254,0.000005239145,0.00005634846,0.00001798942,0.00004325165,0.9976102,0.00008182695,0.0001677512,0.00147931],"study_design_scores_gemma":[0.00005097502,0.000553668,0.00314416,0.000009322063,0.00002243407,0.0002387421,0.00003422125,0.0004496909,0.9916404,0.00005325371,0.003798271,0.000004769169],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895669,0.00468959,0.001992978,0.0004646645,0.0001178074,0.00002943452,0.0004511503,0.0001013755,0.002585998],"genre_scores_gemma":[0.9877747,0.004344814,0.002396162,0.0001301954,0.00003080047,0.00005798061,0.0003795066,0.00002248629,0.004863295],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001821108,"threshold_uncertainty_score":0.006092191,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009969647844947277,"score_gpt":0.224889398078345,"score_spread":0.2149197502333977,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}