{"id":"W2071695207","doi":"10.1111/j.1742-4658.2006.05318.x","title":"Analysis of oxidative events induced by expanded polyglutamine huntingtin exon 1 that are differentially restored by expression of heat shock proteins or treatment with an antioxidant","year":2006,"lang":"en","type":"article","venue":"FEBS Journal","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"","keywords":"Heat shock protein; Hsp70; Cysteine; Glutamine; Biochemistry; Huntingtin; Oxidative stress; Reactive oxygen species; Glutathione; Molecular biology; Oxidative phosphorylation; Cell biology; Heat shock; Chemistry; Biology; Amino acid; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009657205,0.0003341688,0.0006252316,0.0003565483,0.000210147,0.00005892013,0.0003090881,0.00006635311,0.000124531],"category_scores_gemma":[0.00009128634,0.0002124562,0.0001850555,0.0006293032,0.00009716192,0.0002457714,0.00005233974,0.0001419262,6.030723e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000922219,"about_ca_system_score_gemma":0.000117289,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001529946,"about_ca_topic_score_gemma":0.0001642784,"domain_scores_codex":[0.9971235,0.0006054643,0.0005609387,0.0005233015,0.0008385808,0.000348165],"domain_scores_gemma":[0.998383,0.00008505831,0.0008119273,0.0003795775,0.0001483578,0.0001921123],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001044951,0.0016973,0.05987918,0.00001023893,0.00008386524,0.00001833345,0.0001759445,0.0002664505,0.9365022,9.018647e-7,0.0000730645,0.0002476091],"study_design_scores_gemma":[0.001707172,0.001982293,0.151205,0.0001054649,0.0003363017,0.00001275383,0.0001862062,0.0001633315,0.8441029,0.000007379825,0.000006375139,0.000184829],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973949,0.00006886828,0.001556839,0.00004747921,0.00005425703,0.0004769762,0.0003659222,0.00001899371,0.00001582742],"genre_scores_gemma":[0.999032,0.00004321392,0.0004756639,0.00002193153,0.00004417086,0.00003202879,0.00004136418,0.0000339756,0.0002756897],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0923993,"threshold_uncertainty_score":0.8663711,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03591201852622231,"score_gpt":0.2771598168807183,"score_spread":0.241247798354496,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}