{"id":"W2071716295","doi":"10.1016/j.jalz.2010.05.946","title":"P1‐392: Synthesis and evaluation of [18F]fluorinated triazole‐derivatives of the pittsburgh compound as potential PET radiotracers for imaging amyloid plaques","year":2010,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Biodistribution; Imaging agent; Azide; In vivo; Chemistry; Ascorbic acid; Amyloid (mycology); Pittsburgh compound B; Combinatorial chemistry; Biochemistry; In vitro; Medicine; Alzheimer's disease; Pathology; Disease; Biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002090524,0.0003900316,0.0002569048,0.0001696503,0.0001618159,0.0001881821,0.000449727,0.0005947693,0.001361696],"category_scores_gemma":[0.0001676933,0.000184663,0.0002167295,0.0002995641,0.0001512578,0.0002839183,0.0001575824,0.0003676752,0.0006151089],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000259009,"about_ca_system_score_gemma":0.0003114859,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001396438,"about_ca_topic_score_gemma":0.001251478,"domain_scores_codex":[0.9999214,0.00001755786,0.000004774094,0.00001783596,0.00001929711,0.00001908895],"domain_scores_gemma":[0.9999403,0.000007724739,0.00001042875,0.00000635204,0.00001798457,0.00001722726],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001386747,0.0000691283,0.00006405663,0.0001067066,0.000009292454,0.0002759279,0.00003734958,0.0002995109,0.9949826,0.000192034,0.0001675447,0.003657121],"study_design_scores_gemma":[0.00004342082,0.0009029556,0.0006637638,0.000006667899,0.00001775854,0.0006211341,0.000009642288,0.000971359,0.9916991,0.00003831918,0.005013895,0.00001206391],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9669725,0.006962293,0.01789956,0.0002303166,0.00005934084,0.0004786376,0.0008480576,0.0002025575,0.006346808],"genre_scores_gemma":[0.9671518,0.005353472,0.01897921,0.000140068,0.00002705947,0.0002942982,0.001402366,0.0000653631,0.006586284],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001396438,"threshold_uncertainty_score":0.004555345,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02333613583912973,"score_gpt":0.2944989750537877,"score_spread":0.2711628392146579,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}