{"id":"W2071759664","doi":"10.1124/dmd.31.9.1134","title":"BIOTRANSFORMATION OF 4-(METHYLNITROSAMINO)-1-(3-PYRIDYL)-1-BUTANONE (NNK) IN PERIPHERAL HUMAN LUNG MICROSOMES","year":2003,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":60,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"U.S. Public Health Service","keywords":"Biotransformation; Microsome; Human lung; Microsoma; Chemistry; Carcinogen; In vitro; Peripheral; Lung; Pharmacology; Toxicology; Biochemistry; Biology; Medicine; Enzyme; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003879958,0.000370432,0.0003835531,0.0003581796,0.0006026565,0.0003449969,0.0002276471,0.0003563426,0.002057302],"category_scores_gemma":[0.0006412789,0.0003004112,0.0003843331,0.0003683276,0.0002372294,0.0004099435,0.0002528584,0.0004102368,0.0009368812],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005837657,"about_ca_system_score_gemma":0.0009592811,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008119784,"about_ca_topic_score_gemma":0.009734665,"domain_scores_codex":[0.9997203,0.0001054252,0.00001681039,0.00006310317,0.00003727122,0.00005712047],"domain_scores_gemma":[0.9997516,0.0001023407,0.00003309241,0.00004013897,0.00003630431,0.00003645071],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004405986,0.0001788372,0.006516555,0.0001977566,0.0001073638,0.000625385,0.0003324527,0.001265118,0.9726345,0.0009317608,0.000230046,0.01257424],"study_design_scores_gemma":[0.00004669912,0.0007831142,0.01635942,0.0000111225,0.00007644829,0.0005327419,0.00009794965,0.002632004,0.9781935,0.0001532793,0.001097791,0.00001598344],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904587,0.001451358,0.005071972,0.00007564177,0.00002970506,0.00004976103,0.0007155793,0.00009941673,0.002047889],"genre_scores_gemma":[0.9929367,0.0007395084,0.001514164,0.0000186752,0.00001118958,0.00003774114,0.0009475132,0.00002354574,0.003770975],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008119784,"threshold_uncertainty_score":0.01614505,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03190195871812364,"score_gpt":0.3767636877648801,"score_spread":0.3448617290467564,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}