{"id":"W2071759664","doi":"10.1124/dmd.31.9.1134","title":"BIOTRANSFORMATION OF 4-(METHYLNITROSAMINO)-1-(3-PYRIDYL)-1-BUTANONE (NNK) IN PERIPHERAL HUMAN LUNG MICROSOMES","year":2003,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":60,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"U.S. Public Health Service","keywords":"Biotransformation; Microsome; Human lung; Microsoma; Chemistry; Carcinogen; In vitro; Peripheral; Lung; Pharmacology; Toxicology; Biochemistry; Biology; Medicine; Enzyme; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009924677,0.0003076137,0.0004981211,0.0003279566,0.0002441952,0.00003558805,0.000154335,0.0002280699,0.0004108023],"category_scores_gemma":[0.00002834834,0.000305217,0.000128274,0.0003906433,0.0002245152,0.000347449,0.00003379626,0.0004383598,0.000008642418],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003303298,"about_ca_system_score_gemma":0.00005089082,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006751822,"about_ca_topic_score_gemma":0.00002437206,"domain_scores_codex":[0.9976403,0.0006679674,0.0006677159,0.0003562506,0.0002040161,0.0004637089],"domain_scores_gemma":[0.9992265,0.00009377658,0.0001962258,0.000178242,0.00009282817,0.0002124461],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001901787,0.0004774446,0.01004152,0.0001589477,0.00008264131,0.00001016939,0.002858927,0.0002222905,0.9488207,0.02982438,0.0002057224,0.007107044],"study_design_scores_gemma":[0.006001954,0.00003418648,0.06384747,0.00003521508,0.000425341,0.00003113925,0.0005024842,0.001270831,0.8807731,0.003619763,0.04288916,0.0005694114],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9797551,0.01325483,0.0003805007,0.0001612732,0.0006667295,0.0004799947,0.0002154467,0.0000370907,0.005049039],"genre_scores_gemma":[0.9963252,0.002229016,0.0004314955,0.0005004221,0.0001121914,0.00005141465,0.000143732,0.00002721416,0.0001793211],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06804769,"threshold_uncertainty_score":0.99994,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03190195871812364,"score_gpt":0.3767636877648801,"score_spread":0.3448617290467564,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}