{"id":"W2071762596","doi":"10.1021/cc050090+","title":"Peptide−Heterocycle Hybrid Molecules:  Solid-Phase Synthesis of a 400-Member Library of N-Terminal 2-Iminohydantoin Peptides","year":2006,"lang":"es","type":"article","venue":"Journal of Combinatorial Chemistry","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Edman degradation; Chemistry; Peptide; Tripeptide; Solid-phase synthesis; Thiourea; Stereochemistry; Carbodiimide; Molecule; Peptide synthesis; Cleavage (geology); Amide; Electrophile; Combinatorial chemistry; Reagent; Residue (chemistry); Intramolecular force; Organic chemistry; Peptide sequence; Biochemistry; Catalysis; Materials science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001260635,0.0005027616,0.0004965871,0.0003956548,0.0002017255,0.0003396287,0.0003259525,0.0002477941,0.002013953],"category_scores_gemma":[0.0001108167,0.000216645,0.0002127218,0.0004763819,0.0001299589,0.0002242947,0.0002583281,0.0004288212,0.0008300728],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003021588,"about_ca_system_score_gemma":0.0001581194,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000180319,"about_ca_topic_score_gemma":0.0005407953,"domain_scores_codex":[0.9998533,0.00002023907,0.000008570972,0.00003660421,0.00005438253,0.00002695339],"domain_scores_gemma":[0.999925,0.00001398487,0.00001483157,0.000009836185,0.000008373202,0.00002805684],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006841042,0.00006159231,0.00008294745,0.00004336264,0.00001005357,0.0001102154,0.0000160584,0.0004302997,0.994603,0.0001504416,0.00004962026,0.004373874],"study_design_scores_gemma":[0.00003526016,0.0006107636,0.001105874,0.000004412233,0.00002934376,0.0004006815,0.00001383016,0.0009169261,0.9912072,0.00006005745,0.005605888,0.000009908473],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9739852,0.00187692,0.01571694,0.00008050061,0.00005309685,0.0002654819,0.0007696789,0.0003070679,0.006945065],"genre_scores_gemma":[0.9663007,0.00147479,0.02307798,0.00008080983,0.00002550128,0.0002117493,0.001308311,0.00007351857,0.007446717],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002013953,"threshold_uncertainty_score":0.006737351,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005661298114304623,"score_gpt":0.2576499148753515,"score_spread":0.2519886167610469,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}