{"id":"W2071777696","doi":"10.1038/ncomms4771","title":"Transcription factor IRF5 drives P2X4R+-reactive microglia gating neuropathic pain","year":2014,"lang":"en","type":"article","venue":"Nature Communications","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":223,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"Core Research for Evolutional Science and Technology; Japan Science and Technology Agency; Japan Society for the Promotion of Science; Council for Science and Technology Policy; Ministry of Education, Culture, Sports, Science and Technology","keywords":"IRF8; Microglia; IRF5; Neuropathic pain; Interferon regulatory factors; Transcription factor; Medicine; Immunology; Cancer research; Neuroscience; Biology; Gene; Inflammation; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002678669,0.0003217652,0.0002771206,0.0002592054,0.0002693679,0.0003805535,0.0002622168,0.0004173303,0.002409053],"category_scores_gemma":[0.0001289517,0.0001843898,0.000323616,0.0001150069,0.0004892118,0.000271189,0.0002823583,0.0008853956,0.0005438995],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004113286,"about_ca_system_score_gemma":0.0002263474,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004213019,"about_ca_topic_score_gemma":0.0008499122,"domain_scores_codex":[0.9996362,0.00006841688,0.00003347007,0.0000763209,0.00006559913,0.0001200014],"domain_scores_gemma":[0.9998387,0.00002195906,0.00005069651,0.0000218771,0.00001727344,0.00004945252],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008883182,0.00003084631,0.0001150364,0.00002286232,0.00000214734,0.00004224493,0.00001814349,0.00002720861,0.9989527,0.0001464382,0.00002872903,0.0005247284],"study_design_scores_gemma":[0.00003214542,0.0002983292,0.003986789,0.00001527025,0.00001353845,0.0002538605,0.00009014272,0.001057818,0.9927605,0.0001459679,0.001340505,0.000005175234],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927947,0.0005869712,0.003914179,0.0002521506,0.00005037431,0.00003657285,0.0002903777,0.00009704292,0.00197769],"genre_scores_gemma":[0.9937344,0.0003418055,0.002352338,0.0001204428,0.00001754437,0.00005428436,0.0002682609,0.00004019953,0.003070695],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002409053,"threshold_uncertainty_score":0.008059025,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01377347910485571,"score_gpt":0.2694283080793868,"score_spread":0.2556548289745311,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}