{"id":"W2071777696","doi":"10.1038/ncomms4771","title":"Transcription factor IRF5 drives P2X4R+-reactive microglia gating neuropathic pain","year":2014,"lang":"en","type":"article","venue":"Nature Communications","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":223,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"Core Research for Evolutional Science and Technology; Japan Science and Technology Agency; Japan Society for the Promotion of Science; Council for Science and Technology Policy; Ministry of Education, Culture, Sports, Science and Technology","keywords":"IRF8; Microglia; IRF5; Neuropathic pain; Interferon regulatory factors; Transcription factor; Medicine; Immunology; Cancer research; Neuroscience; Biology; Gene; Inflammation; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004752945,0.0001308183,0.000103354,0.0000387795,0.0002400358,0.00002817776,0.0005476828,0.0002674517,0.00001096546],"category_scores_gemma":[0.000591884,0.0001278674,0.00008710286,0.0001007534,0.00008141316,0.000007021058,0.0001141269,0.0005341403,0.000008331955],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009912686,"about_ca_system_score_gemma":0.00002830262,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001279131,"about_ca_topic_score_gemma":0.00003749121,"domain_scores_codex":[0.9986873,0.0006963242,0.0001672398,0.0002116576,0.00008519063,0.0001523178],"domain_scores_gemma":[0.9986475,0.0001666959,0.00009103569,0.000923208,0.0001184759,0.00005308877],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001103396,0.0000605438,0.002065259,0.000007679275,0.00002642576,2.620333e-7,0.0002298657,0.00001714148,0.9883851,0.0008650061,0.003042922,0.005288721],"study_design_scores_gemma":[0.0007098638,0.0002978989,0.01216836,0.00007647971,0.00007129616,0.00002394534,0.0003581764,0.003935811,0.2737494,0.0003742246,0.7076113,0.0006233012],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9105324,0.03032702,0.04477156,0.005857672,0.0004038624,0.0004981816,0.00007560732,0.0001389346,0.007394772],"genre_scores_gemma":[0.9946529,0.0002903624,0.003218214,0.001111635,0.000202961,0.00002011231,0.0002850001,0.00002273736,0.0001961223],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7146357,"threshold_uncertainty_score":0.521428,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01377347910485571,"score_gpt":0.2694283080793868,"score_spread":0.2556548289745311,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}