{"id":"W2071780577","doi":"10.1016/j.jaad.2010.01.030","title":"Efficacy and safety of ABT-874, a monoclonal anti–interleukin 12/23 antibody, for the treatment of chronic plaque psoriasis: 36-week observation/retreatment and 60-week open-label extension phases of a randomized phase II trial","year":2010,"lang":"en","type":"article","venue":"Journal of the American Academy of Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":31,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"","keywords":"Medicine; Psoriasis; Placebo; Adverse effect; Psoriasis Area and Severity Index; Dosing; Internal medicine; Dose; Gastroenterology; Surgery; Dermatology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003351787,0.002264763,0.0038653,0.0006615048,0.0006356615,0.001245612,0.001348706,0.002390179,0.003922363],"category_scores_gemma":[0.002283735,0.00098634,0.002437462,0.000528388,0.002164192,0.001680676,0.0004248352,0.004697327,0.001204523],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009683412,"about_ca_system_score_gemma":0.001166898,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001279559,"about_ca_topic_score_gemma":0.001599628,"domain_scores_codex":[0.9986258,0.0007913422,0.00007739067,0.000176425,0.0001134975,0.0002157101],"domain_scores_gemma":[0.9983488,0.0005106631,0.0002979566,0.0001638809,0.0001112942,0.0005673431],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9677952,0.01127146,0.0006158964,0.000216057,0.0004459616,0.00002197066,0.00005113709,0.0003946546,0.002906224,0.00004585871,0.0003737641,0.01586192],"study_design_scores_gemma":[0.8874772,0.1089429,0.001971364,0.00001421962,0.0003067286,0.00002742062,0.00001593736,0.0004017677,0.0005444768,0.00006647314,0.0002168572,0.00001458359],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935609,0.002754799,0.0003998094,0.0003720438,0.000235762,0.001067478,0.0004832663,0.00008778617,0.001038026],"genre_scores_gemma":[0.991881,0.001893941,0.00105521,0.0006110395,0.0004381142,0.001454062,0.0008989934,0.00003437879,0.001733368],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003922363,"threshold_uncertainty_score":0.01772618,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04806543979036704,"score_gpt":0.3424880558844415,"score_spread":0.2944226160940745,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}