{"id":"W2071822666","doi":"10.1054/drup.2000.0126","title":"Biochemical mechanisms involved in overcoming HIV resistance to nucleoside inhibitors of reverse transcriptase","year":2000,"lang":"en","type":"article","venue":"Drug Resistance Updates","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Medical Research Council; Health Canada","keywords":"Reverse transcriptase; Context (archaeology); Nucleoside; Drug resistance; Biology; Nucleoside Reverse Transcriptase Inhibitor; Enzyme; Drug; Human immunodeficiency virus (HIV); Virology; Amino acid; Genetics; Pharmacology; RNA; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005799754,0.0005759826,0.000426056,0.0007436926,0.0005099688,0.001578878,0.0007101812,0.0009488577,0.002123873],"category_scores_gemma":[0.0005476251,0.0005190673,0.0003536668,0.0003079714,0.000775833,0.001717951,0.0003945844,0.00116621,0.0007334251],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008695928,"about_ca_system_score_gemma":0.0004724577,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005197973,"about_ca_topic_score_gemma":0.0008675593,"domain_scores_codex":[0.999741,0.00007225655,0.00002300274,0.00002562654,0.00007972362,0.00005834518],"domain_scores_gemma":[0.9997843,0.00006048853,0.00006508816,0.00001623716,0.0000536502,0.00002030123],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001144116,0.0005596174,0.002086322,0.001784063,0.00007157181,0.001533106,0.0003829544,0.002643144,0.8192161,0.04449032,0.002303682,0.1237849],"study_design_scores_gemma":[0.0001923886,0.001601069,0.01235007,0.0001783641,0.000179238,0.006215852,0.0005989936,0.006405121,0.8707393,0.01748694,0.08398414,0.00006848315],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5889886,0.3086189,0.02859128,0.0120203,0.00144059,0.0003663579,0.0004778696,0.0006687765,0.05882734],"genre_scores_gemma":[0.8737376,0.1030626,0.009829768,0.00083972,0.0005151874,0.00009940915,0.0003171808,0.00003265174,0.01156594],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002123873,"threshold_uncertainty_score":0.007105052,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006801987319243661,"score_gpt":0.2251592288602605,"score_spread":0.2183572415410168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}