{"id":"W2071822666","doi":"10.1054/drup.2000.0126","title":"Biochemical mechanisms involved in overcoming HIV resistance to nucleoside inhibitors of reverse transcriptase","year":2000,"lang":"en","type":"article","venue":"Drug Resistance Updates","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Medical Research Council; Health Canada","keywords":"Reverse transcriptase; Context (archaeology); Nucleoside; Drug resistance; Biology; Nucleoside Reverse Transcriptase Inhibitor; Enzyme; Drug; Human immunodeficiency virus (HIV); Virology; Amino acid; Genetics; Pharmacology; RNA; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002920231,0.0003156516,0.0005939751,0.0002551328,0.00006812155,0.00001783256,0.0001770785,0.0001069732,0.0005655698],"category_scores_gemma":[0.00007018176,0.0002972959,0.0001448689,0.0006865715,0.000087591,0.0001374541,0.00002520198,0.0001934388,0.0001384436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002433964,"about_ca_system_score_gemma":0.0001098309,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000247203,"about_ca_topic_score_gemma":0.0005581941,"domain_scores_codex":[0.9977983,0.00005858469,0.000686229,0.0005529395,0.0004419879,0.0004619548],"domain_scores_gemma":[0.9990538,0.00007225132,0.00009015392,0.0004655504,0.00007034039,0.0002479267],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007893604,0.001678354,0.02547235,0.001051908,0.0002908642,0.0009206276,0.009563596,0.00001396052,0.3194974,0.005262636,0.627015,0.001339682],"study_design_scores_gemma":[0.004598878,0.00002607691,0.003930583,0.002504603,0.0001356784,0.000003235554,0.001204256,0.0000151962,0.7554456,0.001695204,0.2298629,0.0005778003],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9810832,0.001138389,0.00004629677,0.01207261,0.00007320155,0.0007251552,0.00008095516,0.00008917,0.004691077],"genre_scores_gemma":[0.9227651,0.0002145745,0.02653412,0.0006694918,0.00004245634,0.00007282256,0.0001432674,0.00005131244,0.04950684],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4359482,"threshold_uncertainty_score":0.9999479,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006801987319243661,"score_gpt":0.2251592288602605,"score_spread":0.2183572415410168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}