{"id":"W2071832631","doi":"10.1007/s10571-006-9114-0","title":"Homocysteine Thiolactone and Human Cholinesterases","year":2006,"lang":"en","type":"article","venue":"Cellular and Molecular Neurobiology","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"Mount Saint Vincent University; Dalhousie University","funders":"","keywords":"Hyperhomocysteinemia; Butyrylcholinesterase; Homocysteine; Acetylcholinesterase; Biochemistry; Serine hydrolase; Chemistry; Thiolactone; Acetylcholine; Cholinesterase; Metabolite; Cholinergic; Enzyme; Aché; Pharmacology; Biology; Endocrinology; Serine; Stereochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003780851,0.0003216395,0.0002199366,0.0004928673,0.0001412744,0.0004296092,0.0002263934,0.0004685265,0.002028149],"category_scores_gemma":[0.000428767,0.0001101596,0.00009886722,0.0004586735,0.0003204391,0.0003893012,0.0002147612,0.000298388,0.0003810036],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003998968,"about_ca_system_score_gemma":0.0002470036,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002767862,"about_ca_topic_score_gemma":0.002158253,"domain_scores_codex":[0.9999108,0.00004175958,0.000008988286,0.00001067098,0.00001528403,0.00001257817],"domain_scores_gemma":[0.9998896,0.00004956973,0.00002058398,0.00001053364,0.00001757336,0.00001218643],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.03810034,0.0004340972,0.02633663,0.00204059,0.0005445926,0.005756489,0.001957149,0.003043046,0.6831723,0.0208011,0.004379033,0.2134347],"study_design_scores_gemma":[0.000753338,0.004201881,0.07074995,0.0002110148,0.0004677435,0.007544719,0.001156948,0.002424171,0.7659437,0.01763257,0.1288206,0.00009336849],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.649187,0.330482,0.003508288,0.001616019,0.0001606594,0.00003327836,0.0006223664,0.00008483165,0.01430558],"genre_scores_gemma":[0.9311144,0.05671467,0.0009252705,0.0002262686,0.0001628617,0.00002415056,0.0006420982,0.000006398804,0.0101839],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002767862,"threshold_uncertainty_score":0.006784797,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008849552083660858,"score_gpt":0.2493583914588767,"score_spread":0.2405088393752158,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}