{"id":"W2071885555","doi":"10.1371/journal.pone.0064145","title":"Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Can Mediate Degradation of the Low Density Lipoprotein Receptor-Related Protein 1 (LRP-1)","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":236,"is_retracted":false,"has_abstract":true,"ca_institutions":"Caprion (Canada); Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research","keywords":"PCSK9; LDL receptor; Kexin; Proprotein convertase; Internalization; Endosome; Cell biology; Biology; Receptor; Cholesterol; Chemistry; Cancer research; Lipoprotein; Endocrinology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001885017,0.0001788409,0.0002106833,0.00003434877,0.00008469611,0.00001710167,0.0002152527,0.0002467115,0.0002780122],"category_scores_gemma":[0.0001356126,0.0001408416,0.00008762273,0.0001626723,0.0001332811,0.000009293341,0.00005110511,0.0001757508,0.00005193346],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002300119,"about_ca_system_score_gemma":0.0001116547,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001128417,"about_ca_topic_score_gemma":0.0006552071,"domain_scores_codex":[0.9986883,0.0001112633,0.0003326596,0.0003162206,0.000325922,0.0002255941],"domain_scores_gemma":[0.9988902,0.00000464393,0.0001924364,0.0004875611,0.0003382461,0.00008690264],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009146485,0.0003496639,0.003466628,0.0001193048,0.0001062507,7.364376e-7,0.00007367718,0.000001943842,0.9950942,0.00002621755,0.00002832631,0.0006415691],"study_design_scores_gemma":[0.0004833595,0.0001998047,0.005933107,0.0001427196,0.00005379584,7.873774e-7,0.00002437454,0.0001255106,0.9925805,0.0001111259,0.000166614,0.0001782549],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971394,0.0001988165,0.0001044004,0.0005009772,0.0000616118,0.001863681,0.00002246823,0.00002153217,0.00008711955],"genre_scores_gemma":[0.9948426,0.00003481302,0.0004576667,0.00005163692,0.00006908693,0.0001161631,0.001899073,0.00002920563,0.002499778],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002513672,"threshold_uncertainty_score":0.5743352,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0124762493625813,"score_gpt":0.1750299718438952,"score_spread":0.1625537224813139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}