{"id":"W2071885555","doi":"10.1371/journal.pone.0064145","title":"Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Can Mediate Degradation of the Low Density Lipoprotein Receptor-Related Protein 1 (LRP-1)","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":236,"is_retracted":false,"has_abstract":true,"ca_institutions":"Caprion (Canada); Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research","keywords":"PCSK9; LDL receptor; Kexin; Proprotein convertase; Internalization; Endosome; Cell biology; Biology; Receptor; Cholesterol; Chemistry; Cancer research; Lipoprotein; Endocrinology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001279502,0.0003813788,0.0002479368,0.0002018488,0.000129828,0.0002873983,0.0001161396,0.0002576689,0.001408944],"category_scores_gemma":[0.0001437787,0.0001286374,0.000310219,0.000145378,0.0001536163,0.0001653894,0.0002212931,0.0004767346,0.0006120288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002539667,"about_ca_system_score_gemma":0.0001621941,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005095493,"about_ca_topic_score_gemma":0.0005528595,"domain_scores_codex":[0.9998177,0.0000254833,0.00002519258,0.00003266241,0.00006056103,0.0000385364],"domain_scores_gemma":[0.9999018,0.00001485175,0.00003472928,0.00001589351,0.0000116135,0.00002120448],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001884579,0.00002178461,0.0004299858,0.00007240978,0.00001139734,0.0001871748,0.000007443355,0.00005023764,0.9959643,0.00008351181,0.00008595152,0.002897434],"study_design_scores_gemma":[0.00001920471,0.0002020285,0.007497023,0.0000077803,0.0000159209,0.001172497,0.00001287334,0.0004085013,0.9851918,0.00006621414,0.005401088,0.000004904877],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985944,0.005752902,0.004078241,0.0002178601,0.00009704805,0.00003622086,0.0008197509,0.0001448032,0.002909129],"genre_scores_gemma":[0.9882583,0.002619355,0.00259754,0.00006505752,0.00002018138,0.00002693047,0.001191699,0.00001781959,0.005203135],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001408944,"threshold_uncertainty_score":0.004713356,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0124762493625813,"score_gpt":0.1750299718438952,"score_spread":0.1625537224813139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}