{"id":"W2071888455","doi":"10.1002/ana.10354","title":"Rescue of a mitochondrial deficiency causing Leber hereditary optic neuropathy","year":2002,"lang":"en","type":"article","venue":"Annals of Neurology","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":272,"is_retracted":false,"has_abstract":true,"ca_institutions":"Columbia College","funders":"National Institute of Neurological Disorders and Stroke; National Eye Institute","keywords":"Mitochondrial DNA; Mitochondrion; Oxidative phosphorylation; Point mutation; Leber's hereditary optic neuropathy; Gene; Genetics; Optic neuropathy; Mutation; Protein subunit; Biology; Molecular biology; Biochemistry; Optic nerve","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009584717,0.0005040964,0.0003267911,0.0001980894,0.0001842204,0.000211289,0.0002286089,0.0004049686,0.00123621],"category_scores_gemma":[0.0001336896,0.0001278468,0.000215677,0.0001328457,0.0001690999,0.0001110767,0.0003909222,0.0004658769,0.0003456028],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002674007,"about_ca_system_score_gemma":0.0002176527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009377429,"about_ca_topic_score_gemma":0.0009013055,"domain_scores_codex":[0.9998931,0.00001674546,0.00001578547,0.00002060222,0.00003376095,0.00002010548],"domain_scores_gemma":[0.9998865,0.00002426422,0.0000298311,0.00001534319,0.000009746374,0.0000342946],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003598414,0.000009130994,0.00006357259,0.00002469067,0.000004773104,0.0001506388,0.00001222933,0.00006479739,0.9989249,0.0001136834,0.00003162557,0.0005639908],"study_design_scores_gemma":[0.00004883926,0.000279949,0.0027849,0.0000149558,0.00002557983,0.0008227305,0.00005313341,0.001585322,0.9899564,0.000136927,0.004282849,0.00000842003],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951859,0.0003897294,0.002192707,0.0001226509,0.00004949998,0.0000293913,0.0005565261,0.0001180192,0.001355625],"genre_scores_gemma":[0.9928987,0.0004963271,0.002012688,0.00004676061,0.000008988198,0.00002675971,0.0008209541,0.00007145594,0.003617383],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00123621,"threshold_uncertainty_score":0.004135489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04540807928660463,"score_gpt":0.2735344757737432,"score_spread":0.2281263964871386,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}