{"id":"W2071917878","doi":"10.1074/jbc.m602374200","title":"Auto-activation of the Apoptosis Protein Bax Increases Mitochondrial Membrane Permeability and Is Inhibited by Bcl-2","year":2006,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":152,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Institute of General Medical Sciences","keywords":"Apoptosis; Cell biology; Mitochondrion; Bcl-2-associated X protein; Peptide; Bcl-2 family; Liposome; Chemistry; Biology; Programmed cell death; Biochemistry; Caspase 3","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015001,0.0002230333,0.0002138782,0.0001391098,0.0001314494,0.0003271707,0.000147533,0.0002023813,0.002065226],"category_scores_gemma":[0.0002426135,0.000123792,0.0001839118,0.0001107105,0.0001758462,0.0002883971,0.0003162095,0.0005079955,0.0005116403],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001916435,"about_ca_system_score_gemma":0.0001293366,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001308246,"about_ca_topic_score_gemma":0.0001727986,"domain_scores_codex":[0.9998208,0.00003805077,0.00001082741,0.00002193271,0.00005017192,0.00005824343],"domain_scores_gemma":[0.9998337,0.00004679864,0.00003530748,0.00002511083,0.00001784555,0.00004114716],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001128104,0.00003714962,0.0001278562,0.00003096077,0.000003869611,0.00003932853,0.000009478473,0.00003094167,0.9985239,0.0001139346,0.00003391518,0.0009357541],"study_design_scores_gemma":[0.00003964873,0.0002765778,0.006277601,0.000006339339,0.000009045514,0.0003940448,0.00001979726,0.0008486056,0.9901295,0.0001278047,0.001867687,0.000003248073],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945344,0.001891977,0.001677952,0.0001003023,0.00002316684,0.000009155086,0.0000492117,0.00008164097,0.001632297],"genre_scores_gemma":[0.9971594,0.000645117,0.0005268896,0.00004398965,0.00001164861,0.00001228991,0.00009463449,0.000009291643,0.001496708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002065226,"threshold_uncertainty_score":0.006908834,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007275862055005159,"score_gpt":0.2077420312573384,"score_spread":0.2004661692023333,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}