{"id":"W2071917878","doi":"10.1074/jbc.m602374200","title":"Auto-activation of the Apoptosis Protein Bax Increases Mitochondrial Membrane Permeability and Is Inhibited by Bcl-2","year":2006,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":152,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Institute of General Medical Sciences","keywords":"Apoptosis; Cell biology; Mitochondrion; Bcl-2-associated X protein; Peptide; Bcl-2 family; Liposome; Chemistry; Biology; Programmed cell death; Biochemistry; Caspase 3","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000141899,0.0001096531,0.0001685068,0.000008395813,0.00005265025,0.00001156662,0.0001084939,0.0002546078,0.00005244243],"category_scores_gemma":[0.0001447611,0.00006350769,0.0001322593,0.00005679493,0.0001303887,0.000004091256,0.00006160643,0.0001077558,1.005345e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001583684,"about_ca_system_score_gemma":0.00003296514,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003126836,"about_ca_topic_score_gemma":3.869577e-7,"domain_scores_codex":[0.9992094,0.00005162857,0.0003468555,0.0001581667,0.0001349016,0.00009903719],"domain_scores_gemma":[0.9993372,0.00001632331,0.0003448107,0.0001341816,0.0001248831,0.00004262926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001574417,0.0001266581,0.0006278688,0.0000331661,0.00001687408,1.580243e-7,0.000003972056,0.000007930094,0.9980235,0.000004532485,0.0005698046,0.0004280914],"study_design_scores_gemma":[0.0004939569,0.0001334597,0.001957042,0.00003323922,0.0000139602,0.00001102118,0.00001937653,0.00003318715,0.9943563,0.0002217207,0.002645988,0.0000807476],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99891,0.0002774023,0.0002077418,0.0002183954,0.00003358975,0.0001128213,0.00002120902,0.000002712511,0.0002161939],"genre_scores_gemma":[0.9989609,0.00005252961,0.0003263494,0.00003822674,0.0002747744,0.000003330508,0.00003117069,0.000005008608,0.0003077345],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003667202,"threshold_uncertainty_score":0.2589768,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007275862055005159,"score_gpt":0.2077420312573384,"score_spread":0.2004661692023333,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}