{"id":"W2071927814","doi":"10.1016/j.jsbmb.2009.11.005","title":"Opposing actions of the progesterone metabolites, 5α-dihydroprogesterone (5αP) and 3α-dihydroprogesterone (3αHP) on mitosis, apoptosis, and expression of Bcl-2, Bax and p21 in human breast cell lines","year":2009,"lang":"en","type":"article","venue":"The Journal of Steroid Biochemistry and Molecular Biology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; Canadian Breast Cancer Research Alliance; Susan G. Komen; Breast Cancer Alliance","keywords":"Mitosis; Apoptosis; Biology; Cell growth; Mitotic index; Cell cycle; Estrogen; Cell culture; Cell; Endocrinology; Thymidine; Internal medicine; Cell biology; Biochemistry; In vitro; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003776129,0.000278308,0.0004169368,0.00007213472,0.0001241866,0.00002013983,0.0002077318,0.0003315433,6.874894e-7],"category_scores_gemma":[0.00002552012,0.0001711347,0.00007625857,0.00009763985,0.0005028447,0.00001336336,0.0001795304,0.0003223777,3.853074e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008472914,"about_ca_system_score_gemma":0.00003432151,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007839633,"about_ca_topic_score_gemma":9.960803e-7,"domain_scores_codex":[0.9985507,0.0002459081,0.0005548239,0.000286679,0.0001233504,0.0002385964],"domain_scores_gemma":[0.9989435,0.0000337002,0.0005353644,0.000291779,0.00007920087,0.0001164343],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003365873,0.000197337,0.001695802,0.000108471,0.00006730841,0.000002428008,0.0001124002,0.000006798932,0.9962181,0.00001084443,0.00001291876,0.001230994],"study_design_scores_gemma":[0.001407049,0.001267496,0.002025372,0.0002894223,0.0001446454,0.0006395165,0.0001541489,0.000007216207,0.993778,0.00007155155,0.00005197408,0.0001635695],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9740078,0.02517438,0.00004145139,0.0004543163,0.00004142854,0.0002287127,0.00001781929,0.000002807303,0.00003124202],"genre_scores_gemma":[0.9967413,0.002823858,0.0001973527,0.0001160544,0.00006424916,0.000003370217,0.00001299346,0.0000161014,0.00002472148],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02273346,"threshold_uncertainty_score":0.6978673,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005425462224617101,"score_gpt":0.2480939765184692,"score_spread":0.2426685142938521,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}