{"id":"W2071927814","doi":"10.1016/j.jsbmb.2009.11.005","title":"Opposing actions of the progesterone metabolites, 5α-dihydroprogesterone (5αP) and 3α-dihydroprogesterone (3αHP) on mitosis, apoptosis, and expression of Bcl-2, Bax and p21 in human breast cell lines","year":2009,"lang":"en","type":"article","venue":"The Journal of Steroid Biochemistry and Molecular Biology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; Canadian Breast Cancer Research Alliance; Susan G. Komen; Breast Cancer Alliance","keywords":"Mitosis; Apoptosis; Biology; Cell growth; Mitotic index; Cell cycle; Estrogen; Cell culture; Cell; Endocrinology; Thymidine; Internal medicine; Cell biology; Biochemistry; In vitro; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002242583,0.0001693373,0.0002546388,0.0003409069,0.0002191919,0.0004004207,0.0001423686,0.0002419755,0.00130683],"category_scores_gemma":[0.000413899,0.0002496911,0.0001756804,0.0002966964,0.0003004118,0.0003146173,0.000171684,0.0003622922,0.000191216],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002577323,"about_ca_system_score_gemma":0.0002792466,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008460424,"about_ca_topic_score_gemma":0.001609233,"domain_scores_codex":[0.9997861,0.00004796842,0.00002294524,0.00002765012,0.00005901122,0.00005629811],"domain_scores_gemma":[0.9997123,0.0001248853,0.00004314849,0.00003297807,0.00003185299,0.00005484316],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002395782,0.00006696947,0.001603156,0.00008049054,0.00001718667,0.0003092891,0.0001551818,0.00008120768,0.9915314,0.0002951832,0.00007357943,0.003390711],"study_design_scores_gemma":[0.0001459443,0.001560598,0.03746045,0.00001301025,0.0000609098,0.001184921,0.0003043165,0.0003445603,0.9554727,0.0002066682,0.003237529,0.000008382917],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958122,0.002908149,0.0001503115,0.00006537499,0.00001880071,0.000008441387,0.0002143715,0.000008859128,0.0008135623],"genre_scores_gemma":[0.9956299,0.001922824,0.000219037,0.00004202939,0.00001326089,0.00001753804,0.0003788328,0.000003111015,0.001773455],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00130683,"threshold_uncertainty_score":0.004371762,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005425462224617101,"score_gpt":0.2480939765184692,"score_spread":0.2426685142938521,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}