{"id":"W2071944097","doi":"10.1073/pnas.1312570111","title":"Loss of the tumor suppressor LKB1 promotes metabolic reprogramming of cancer cells via HIF-1α","year":2014,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":290,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"National Cancer Institute; Canadian Institutes of Health Research; Howard Hughes Medical Institute","keywords":"Kinase; Suppressor; Cancer cell; Cell biology; Biology; Cancer research; Hypoxia-inducible factors; Cell growth; Serine; Glycolysis; Cancer; Metabolism; Biochemistry; Phosphorylation; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009919578,0.0001019891,0.0002162326,0.00005622186,0.0001008684,0.000009005597,0.0008823514,0.00007706985,0.000007759868],"category_scores_gemma":[0.0003903195,0.00006049395,0.0001534188,0.0004116206,0.001036172,0.00002031697,0.0002207884,0.00009334921,1.380138e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005235001,"about_ca_system_score_gemma":0.00006214962,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005422418,"about_ca_topic_score_gemma":0.000001155893,"domain_scores_codex":[0.998541,0.00001330327,0.0003478217,0.0002622314,0.0006753222,0.0001603507],"domain_scores_gemma":[0.9988396,0.00002709181,0.0006929689,0.00003014506,0.000381217,0.00002898937],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001741218,0.00003959774,0.002834735,0.00008313969,0.00002735121,4.141307e-10,0.00008715889,0.00004460305,0.9935417,0.001558261,0.0003657545,0.001400255],"study_design_scores_gemma":[0.0001785623,0.00003674703,0.02028812,0.00005158056,0.00003852703,0.000002386337,0.00003850097,0.0001082574,0.9667848,0.001954115,0.01045048,0.00006796371],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996072,0.002231411,0.000002896852,0.0007093179,0.0001270958,0.0002200966,0.00003225253,0.000002649237,0.0006023148],"genre_scores_gemma":[0.9984128,0.0001854784,0.0007545641,0.0001263008,0.0003480526,0.00001805544,2.035146e-7,0.000005747988,0.0001488004],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02675697,"threshold_uncertainty_score":0.3817821,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01656064588708724,"score_gpt":0.2855867486831276,"score_spread":0.2690261027960403,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}