{"id":"W2071947905","doi":"10.2174/0929867033456585","title":"Novel Hydroxamate and Anilide Derivatives as Potent Histone Deacetylase Inhibitors: Synthesis and Antiproliferative Evaluation","year":2003,"lang":"en","type":"review","venue":"Current Medicinal Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pyrogenesis (Canada)","funders":"","keywords":"Histone deacetylase; Trichostatin A; Hydroxamic acid; Acetylation; Cell growth; Histone; Chemistry; Cell cycle; Cancer cell; Histone deacetylase inhibitor; Histone deacetylase 5; Histone deacetylase 2; Cell cycle checkpoint; Biochemistry; Cancer research; Biology; Cancer; Cell; Gene; Genetics; Stereochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001474514,0.0006224847,0.0003606212,0.0003823457,0.0001267699,0.0002209499,0.000430723,0.0003071091,0.002967169],"category_scores_gemma":[0.00009933757,0.0001451451,0.0002028531,0.0002835517,0.0001453579,0.0003284634,0.0001882598,0.000478442,0.0008029355],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002981099,"about_ca_system_score_gemma":0.0002004759,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000486862,"about_ca_topic_score_gemma":0.0008849575,"domain_scores_codex":[0.9999545,0.000007317436,0.00000497371,0.00000889463,0.00001161023,0.00001279063],"domain_scores_gemma":[0.9999529,0.000006220129,0.00001006735,0.000003348686,0.000009321797,0.00001819862],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004713773,0.0004555512,0.0001790325,0.0008121555,0.00004171899,0.0002848791,0.00007548228,0.001850267,0.8989426,0.001792056,0.00112189,0.09397295],"study_design_scores_gemma":[0.0005146828,0.01017987,0.003597605,0.0001103351,0.0001615505,0.001223299,0.00004853234,0.00229721,0.8639401,0.0004845606,0.1173899,0.00005232371],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.6539374,0.2759183,0.02859776,0.0006838674,0.0006548035,0.0009979287,0.001773484,0.0006511658,0.0367852],"genre_scores_gemma":[0.7828754,0.185755,0.0141863,0.0003776623,0.0003365183,0.0003242345,0.001520472,0.00005515164,0.01456934],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.002967169,"threshold_uncertainty_score":0.0099262,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05243561106004767,"score_gpt":0.3938725110748181,"score_spread":0.3414369000147704,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}