{"id":"W2071968656","doi":"10.1016/j.ultrasmedbio.2012.01.023","title":"Increased Accumulation and Retention of Micellar Paclitaxel in Drug-Sensitive and P-Glycoprotein–Expressing Cell Lines Following Ultrasound Exposure","year":2012,"lang":"en","type":"article","venue":"Ultrasound in Medicine & Biology","topic":"Ultrasound and Hyperthermia Applications","field":"Engineering","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Institute for Computing, Information and Cognitive Systems; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Paclitaxel; P-glycoprotein; Chemistry; Intracellular; Micelle; Efflux; Ultrasound; Cell culture; Pharmacology; Cytotoxicity; Doxorubicin; Ethylene glycol; Drug; In vitro; Biophysics; Biochemistry; Medicine; Chemotherapy; Multiple drug resistance; Surgery; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002016947,0.0002447825,0.0003808293,0.0002398226,0.0002307928,0.000502517,0.0001955977,0.0003525062,0.001313627],"category_scores_gemma":[0.0002403862,0.000199824,0.0003131124,0.0003364538,0.0003323713,0.0004135855,0.0001665209,0.0005260998,0.0003866112],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004157016,"about_ca_system_score_gemma":0.000242617,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002448603,"about_ca_topic_score_gemma":0.001732974,"domain_scores_codex":[0.9997801,0.00003916262,0.00001914822,0.00003833624,0.00006042566,0.00006283569],"domain_scores_gemma":[0.9998103,0.00007186941,0.00003480266,0.00002753695,0.00003376337,0.00002181058],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008917449,0.00001787176,0.00008311072,0.000009714639,0.000003486989,0.0000292686,0.00003421425,0.00004248764,0.9992872,0.00004220149,0.00002360703,0.0003377206],"study_design_scores_gemma":[0.000005631332,0.0001399317,0.001734725,0.000001327851,0.000009370194,0.00007162189,0.0000284431,0.0004365923,0.9971864,0.000009826072,0.0003729229,0.000003264721],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956788,0.0008318164,0.002154482,0.00008374961,0.00002283229,0.00001403137,0.0002418803,0.00006215029,0.0009103501],"genre_scores_gemma":[0.9948772,0.0004405392,0.001067845,0.00003573822,0.000008337735,0.00002786589,0.0004163177,0.00002811309,0.003098102],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002448603,"threshold_uncertainty_score":0.004868746,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01705309927027784,"score_gpt":0.2615560455919055,"score_spread":0.2445029463216277,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}