{"id":"W2071974827","doi":"10.1111/j.1747-0285.2008.00638.x","title":"Synthesis of Water Soluble Bis‐triazenoquinazolines: An Unusual Predicted Mode of Binding to the Epidermal Growth Factor Receptor Tyrosine Kinase","year":2008,"lang":"en","type":"article","venue":"Chemical Biology & Drug Design","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Royal Victoria Hospital","funders":"Canadian Institutes of Health Research; McGill University","keywords":"Moiety; Linker; Tyrosine kinase; Epidermal growth factor receptor; Chemistry; Tyrosine; Stereochemistry; Receptor tyrosine kinase; Ring (chemistry); Binding site; Molecular model; Growth factor receptor; Molecule; Biophysics; Epidermal growth factor; Autophosphorylation; Receptor; Biochemistry; Kinase; Biology; Protein kinase A; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000129782,0.0003688395,0.0003208374,0.0001051438,0.00009187467,0.000201104,0.0003964767,0.0002942614,0.0007827966],"category_scores_gemma":[0.0001345072,0.0001599925,0.0001821322,0.0001344237,0.0001652456,0.0002705086,0.0001660095,0.0003729288,0.000384046],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002171701,"about_ca_system_score_gemma":0.0001826466,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002284692,"about_ca_topic_score_gemma":0.0005403625,"domain_scores_codex":[0.9999205,0.00001310442,0.000006680725,0.00001991037,0.00002138056,0.00001846795],"domain_scores_gemma":[0.9999264,0.00001078703,0.00002532737,0.000007957487,0.00001168351,0.00001782594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005485455,0.00002143821,0.00006266451,0.00005737321,0.000006515136,0.00009068472,0.00001989825,0.0003486046,0.9946642,0.0004742053,0.00005898272,0.004140499],"study_design_scores_gemma":[0.00006271754,0.0006157716,0.0004493312,0.000003829703,0.00001781551,0.000329795,0.00001010068,0.001215583,0.9915624,0.0001092849,0.005610634,0.0000126603],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9452927,0.004254721,0.04438272,0.0001958411,0.00008744562,0.0002210247,0.0004582425,0.0004359199,0.004671304],"genre_scores_gemma":[0.9713827,0.001970238,0.0232107,0.00005843664,0.00001586174,0.00007734211,0.0003551589,0.00003886154,0.002890651],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007827966,"threshold_uncertainty_score":0.00261867,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03367568953119485,"score_gpt":0.2703191052526289,"score_spread":0.2366434157214341,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}