{"id":"W2071974827","doi":"10.1111/j.1747-0285.2008.00638.x","title":"Synthesis of Water Soluble Bis‐triazenoquinazolines: An Unusual Predicted Mode of Binding to the Epidermal Growth Factor Receptor Tyrosine Kinase","year":2008,"lang":"en","type":"article","venue":"Chemical Biology & Drug Design","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Royal Victoria Hospital","funders":"Canadian Institutes of Health Research; McGill University","keywords":"Moiety; Linker; Tyrosine kinase; Epidermal growth factor receptor; Chemistry; Tyrosine; Stereochemistry; Receptor tyrosine kinase; Ring (chemistry); Binding site; Molecular model; Growth factor receptor; Molecule; Biophysics; Epidermal growth factor; Autophosphorylation; Receptor; Biochemistry; Kinase; Biology; Protein kinase A; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001474661,0.0002791195,0.0004967836,0.00005071009,0.0001487609,0.000006478018,0.000676922,0.0003186121,0.0004542046],"category_scores_gemma":[0.0005545116,0.0001866238,0.0001494741,0.0002277219,0.0004624575,0.0000626472,0.0001605215,0.0002542667,0.00002394624],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005186645,"about_ca_system_score_gemma":0.00007716425,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005725525,"about_ca_topic_score_gemma":7.597758e-7,"domain_scores_codex":[0.9981967,0.00006879838,0.0006379514,0.0004985151,0.0001424073,0.0004556795],"domain_scores_gemma":[0.9980922,0.000753391,0.0001804223,0.0005943293,0.0001782275,0.0002014156],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002143234,0.000312435,0.000862934,0.00007281516,0.00006187196,0.000001160612,0.000404872,0.00002340514,0.9955484,0.00004207438,0.002209881,0.0002458795],"study_design_scores_gemma":[0.0003567224,0.00002426881,0.00001458022,0.00004234185,0.00005022819,0.00001159225,0.00009042977,0.0001952624,0.9979763,0.0000759422,0.0009437448,0.0002186112],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972402,0.00003915481,0.0007817835,0.0008661435,0.00004482455,0.0001826344,0.0005634577,0.00009020371,0.0001915711],"genre_scores_gemma":[0.9973136,0.00004089554,0.001464889,0.00005550301,0.0002630167,0.0001556758,0.0003917051,0.00003215684,0.0002826259],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002427928,"threshold_uncertainty_score":0.7610297,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03367568953119485,"score_gpt":0.2703191052526289,"score_spread":0.2366434157214341,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}