{"id":"W2071975518","doi":"10.1126/science.1215327","title":"The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase","year":2012,"lang":"en","type":"article","venue":"Science","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":733,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; National Institutes of Health; Wellcome Trust; Yale University","keywords":"AMPK; AMP-activated protein kinase; Protein kinase A; Adenosine monophosphate; Adenosine triphosphate; Adenosine; Adenosine diphosphate; Chemistry; Aspirin; Kinase; Adenylate kinase; Phosphorylation; Biochemistry; Pharmacology; Cell biology; Biology; Enzyme; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009104617,0.0001162312,0.00008051132,0.00002828139,0.000426301,0.00008021703,0.0004179959,0.00003648821,0.0000211653],"category_scores_gemma":[0.0002573971,0.00007572172,0.00004283603,0.0003423531,0.0004964264,0.00002216383,0.0001429518,0.00007254306,0.00003251299],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002521212,"about_ca_system_score_gemma":0.0001528932,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002243453,"about_ca_topic_score_gemma":0.00001617227,"domain_scores_codex":[0.9986956,0.00005670341,0.0001128875,0.0002851895,0.0002691137,0.0005805501],"domain_scores_gemma":[0.9992206,0.00001136463,0.0000723128,0.0004276074,0.00009648558,0.0001716111],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001491899,0.00002586433,0.0002775442,0.000002599653,0.000004606674,8.121356e-8,0.00009988062,0.000002775417,0.9626426,0.0001147696,0.00074318,0.03607118],"study_design_scores_gemma":[0.0000600428,0.000009784725,0.002014573,0.00000394804,0.000001907109,4.770413e-7,0.00002033742,0.00000276386,0.5692337,0.00002894325,0.4285496,0.00007387557],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9355021,0.06288616,0.00003738057,0.00006987293,0.0004609123,0.0001880046,0.000006287808,0.00001561736,0.0008337029],"genre_scores_gemma":[0.9964946,0.001673094,0.0002137647,0.0002853928,0.0002732676,0.00005472148,0.000005206264,0.00001065257,0.0009893305],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4278064,"threshold_uncertainty_score":0.3278806,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01111002916811103,"score_gpt":0.2647178993471286,"score_spread":0.2536078701790176,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}