{"id":"W2071991687","doi":"10.2165/00003088-200544050-00003","title":"Pharmacokinetic Profile of Ganciclovir After its Oral Administration and From its Prodrug, Valganciclovir, in Solid Organ Transplant Recipients","year":2005,"lang":"en","type":"article","venue":"Clinical Pharmacokinetics","topic":"Cytomegalovirus and herpesvirus research","field":"Medicine","cited_by":129,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto General Hospital; University of Toronto","funders":"","keywords":"Valganciclovir; Ganciclovir; Pharmacokinetics; Medicine; Prodrug; NONMEM; Population; Dosing; Pharmacology; Internal medicine; Human cytomegalovirus; Immunology; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000442682,0.000368604,0.0005906679,0.0002898611,0.0002362018,0.0008589558,0.0002016992,0.0004315969,0.00150998],"category_scores_gemma":[0.00208619,0.0002603634,0.0003466138,0.0002754687,0.000418756,0.0005388884,0.000128014,0.0009053973,0.000528422],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007437784,"about_ca_system_score_gemma":0.0005296168,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001837965,"about_ca_topic_score_gemma":0.0009747499,"domain_scores_codex":[0.999745,0.0001077664,0.00001265218,0.00004167524,0.00003797485,0.00005499947],"domain_scores_gemma":[0.9994584,0.0002039295,0.0001035282,0.00004042823,0.00003407321,0.0001596536],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.3013989,0.002572237,0.08327999,0.0003748293,0.0005226484,0.003329849,0.001199695,0.009437331,0.3782575,0.001408251,0.003657553,0.2145613],"study_design_scores_gemma":[0.007808425,0.1332604,0.5623351,0.0001095864,0.001436332,0.01259696,0.001093566,0.02939075,0.2342654,0.001599007,0.01578526,0.0003193325],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964461,0.001472904,0.0004006831,0.00006559733,0.00002256593,0.00002350333,0.000184868,0.00005192171,0.001331922],"genre_scores_gemma":[0.9988158,0.0002412308,0.0001075314,0.00005658311,0.00002756697,0.00001101662,0.0001638636,0.00001690048,0.0005594729],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001837965,"threshold_uncertainty_score":0.005396485,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06633831168241856,"score_gpt":0.4240387186570174,"score_spread":0.3577004069745988,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}