{"id":"W2072038477","doi":"10.1021/jm060827p","title":"A Potent, Covalent Inhibitor of Orotidine 5‘-Monophosphate Decarboxylase with Antimalarial Activity","year":2007,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"National Center for Research Resources","keywords":"Chemistry; Covalent bond; Stereochemistry; Active site; Nucleoside; Inosine monophosphate; Enzyme; Biochemistry; Nucleotide; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001125069,0.0001414783,0.000348582,0.00004383238,0.00004114124,0.00001139962,0.0001592551,0.0001071022,0.0001876644],"category_scores_gemma":[0.0001476463,0.00009399743,0.00008124181,0.0001376902,0.000127001,0.0001489227,0.00002026525,0.0003124334,0.000001308568],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000693578,"about_ca_system_score_gemma":0.0001665472,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001397803,"about_ca_topic_score_gemma":0.000002454667,"domain_scores_codex":[0.9984831,0.00001910387,0.0004585746,0.0001343235,0.0006902051,0.0002146495],"domain_scores_gemma":[0.9985636,0.000069043,0.0007399917,0.0001437057,0.0002987117,0.000184927],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003194524,0.00009708969,0.0009243797,0.00009912179,0.00002305683,0.0002221909,0.00006192303,0.00002885767,0.9932261,0.000004439905,0.000350789,0.001767498],"study_design_scores_gemma":[0.001813903,0.0007134673,0.006459994,0.0002345586,0.0001000301,0.00077059,0.00009953194,0.000008148932,0.989428,0.00003685221,0.0002414726,0.00009342204],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951105,0.0002445634,0.002839484,0.0001695856,0.0005240165,0.00005211732,0.000004024558,0.00000863498,0.001047124],"genre_scores_gemma":[0.9970366,0.00002414125,0.001462339,0.00004577794,0.001362515,2.792915e-7,9.180019e-7,0.000008847581,0.00005851605],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005535615,"threshold_uncertainty_score":0.3833104,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005203919731190602,"score_gpt":0.225385339346516,"score_spread":0.2201814196153254,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}